Author(s): Minakshi D. Pawara, Amod S. Patil, Mangesh S. Ghodke

Email(s): minaxipawara@gmail.com , mangeshsghodke@gmail.com , patilamod.s@gmail.com

DOI: 10.52711/2231-5675.2021.00019   

Address: Minakshi D. Pawara1, Amod S. Patil2*, Mangesh S. Ghodke3
1M. Pharm. Student, Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule (MS) 425405.
2Assistant Professor, Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule (MS) 425405.
3Assistant Professor, Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule (MS) 425405.
*Corresponding Author

Published In:   Volume - 11,      Issue - 2,     Year - 2021


ABSTRACT:
The purpose of this study is to establish Novel Zero-order UV-Spectrophotometric - absorbance and Zero Order- Area under curve (AUC) methods for estimation of Fenticonazole Nitrate in bulk and vaginal capsules with the application of hydrotropic solubilization phenomenon. Fenticonazole Nitrate is an antifungal drug and it is completely insoluble in water. Pluronic F127 (10% w/v) solution was used as solvent for solubilization of Fenticonazole Nitrate. Maximum absorption for Fenticonazole Nitrate was found to be at wavelength 253nm when dissolved in Pluronic F127 (10% w/v) solution. The methods are based upon measurement of absorbance at 253nm and integration of area under curve for analysis of Fenticonazole Nitrate in the wavelength range of 242.2-261.6nm. The drug followed linearity in the concentration range of 8 - 40µg/mL with correlation coefficient value r2> 0.99 for both methods. The proposed methods were validated for accuracy (% recovery), precision, repeatability and ruggedness, as per ICH guidelines. The proposed methods were applied for qualitative and quantitative estimation of Fenticonazole Nitrate in vaginal capsules and results were found in good agreement with the label claimed. Developed methods can be used for routine analysis of Fenticonazole Nitrate in bulk and Vaginal Capsules.


Cite this article:
Minakshi D. Pawara, Amod S. Patil, Mangesh S. Ghodke. Application of Hydrotropic Solubilization Phenomenon for Estimation of Fenticonazole in Bulk and Vaginal capsules using UV-spectrophotometry Methods. Asian Journal of Pharmaceutical Analysis. 2021; 11(2):113-7. doi: 10.52711/2231-5675.2021.00019

Cite(Electronic):
Minakshi D. Pawara, Amod S. Patil, Mangesh S. Ghodke. Application of Hydrotropic Solubilization Phenomenon for Estimation of Fenticonazole in Bulk and Vaginal capsules using UV-spectrophotometry Methods. Asian Journal of Pharmaceutical Analysis. 2021; 11(2):113-7. doi: 10.52711/2231-5675.2021.00019   Available on: https://ajpaonline.com/AbstractView.aspx?PID=2021-11-2-9


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