Author(s): Surbhi Choursiya, Arpana Indurkhya

Email(s): ,

DOI: 10.5958/2231-5675.2020.00027.7   

Address: Surbhi Choursiya, Arpana Indurkhya
Sri Aurobindo Institute of Pharmacy, Indore.
*Corresponding Author

Published In:   Volume - 10,      Issue - 3,     Year - 2020

The objective of the present study was to developed and evaluate of the hard candy lozenges containing roxithromycin for the treatment of oral bacterial infection. The mouth of human body provides non-shedding surfaces (teeth) for natural microbial colonization. These can the accumulation of large masses of bacteria and their products at stagnant sites. Dental plaque and gingivitis are some of this type of conditions, which can develop due to microbial accumulation on teeth and mouth ulcers are small, painful sores on the inside lining of the mouth. In this current study, Roxithromycin macrolide category wide spectrum antibacterial drug was selected as a drug because the existing market product of Roxithromycin is not available in the form of lozenges that can deliver the drug from the oral cavity. In the present investigation, taste is one of the most important parameters of oral formulations so ß-Cyclodextrin is used as a good taste masking agent for bitter drug and also enhances the solubility of the drug. Hard candy lozenges were formulated by heating and Congealing technique with exicipients like sucrose, Isomalt, Glycerin, citric acid, flavor and color and evaluated for organoleptic properties the test like diameter, thickness, weight variation, hardness, friability, mouth dissolving time, and % drug content. The Optimized formulation of Roxithromycin Hard candy lozenges (H6) were sweet in taste, smooth in texture and having a diameter 13.708±0.00 mm, thickness 7.704±0.00 mm, hardness is 11±1kg/cm2 and drug content uniformity is 97±0.02%. The weight variation and friability of lozenges (H6) was passed as per IP and mouth dissolving time is found at 25±2 min. In vitro dissolution study for roxithromycin hard candy lozenges lozenge was performed in pH 6.8 phosphate buffers wherein 95% of the drug was released within 30 min.

Cite this article:
Surbhi Choursiya, Arpana Indurkhya. Development and Evaluation of Hard Candy Lozenges Containing Roxithromycin for Treatment of Oral Infection. Asian J. Pharm. Ana. 2020; 10(3):150-154. doi: 10.5958/2231-5675.2020.00027.7

Surbhi Choursiya, Arpana Indurkhya. Development and Evaluation of Hard Candy Lozenges Containing Roxithromycin for Treatment of Oral Infection. Asian J. Pharm. Ana. 2020; 10(3):150-154. doi: 10.5958/2231-5675.2020.00027.7   Available on:

1. Meghwal M, Goswami TK. Chemical Composition, Nutritional, Medicinal and Functional Properties of Black Pepper: A Review. Open Acc Sci Rep. 2012; 1:1-5.
2. Paul M, ESCMID Guideline for the Management of Acute Sore Throat, 2012; 18: ESCMID, 1-18.
3. Maheshwari Rachana, Jain Vikas, Ansari Rehana et al. A Review on lozenges. Journal Home Page 2013; 1(1): 35-43.
4. Munot M., Sharma Neha, Gujar N. Kishore. Orodental Delivery Systems. International Journal of Pharm. and Pharmaceutical Science. 2013; 5(3):1-10.
5. Maheshwari R, Jain V, Ansari R, Mahajan SC, Joshi G. A review on lozenges. BBB, 2013; 1-9.
6. Shinde SG, Kadam V, Kapse GR, Jadhav SB, Zameeruddin, Bharkad VB. A review on lozenges. IAJPR, 2014; 4(2): 567-570
7. Pothu R and Yamsani MR. Lozenges formulation and evaluation: A review. IJAPR. 2014; 1: 290-294.
8. Shinde Satish G, Kadam Vaishali, Kapse al. A Review on lozenges. Indo American Journal of Pharmaceutical Research. 2014; 4(1): 566-571.
9. Pundir Suchitra, Verma Abhay, Murari Lal. A Review on lozenges. Journal der Pharma. Forschung. 2014; 2(1): 1-10.
10. Stephen O. Majekodunmi. A Review on Lozenges. American Journal of Medicine and Medical Sciences. 2015; 5(2): 99-104.
11. Adavelly Manasa, Amma Venu, Velpula Rajeshwari. Formulation and Evaluation of Cetrizine Lozenges. International Journal of Innovative Pharmaceutical Sciences and Research. 2017; 5 (10): 93-103.
12. Mishra Kamlendra, Kutubuddin Tasneem, Jain Vikas et al. Formulation and Evaluation of Herbal Lozenges. Research Journal of Drug Delivery and Therapeutics. 2017; 7(7): 1124-1129.
13. Mayuri J. Chandrawanshi, R. S. Sakhare, Dr. Shivappa N. Nagoba  et al.  A Review on Medicated Lozenges. World Journal of Pharmaceutical Research. 2018; 8 (2): 396-412.
14. Pokale Apurva D., Dr. K Shrikant. Tillooand et al. Medicated Chewable Lozenges: A Review. International Journal of Recent Scientific Research. 2019; 10(4): 32071-32076. 
15.  Chaudhari V Punam, Chaudhari Nirma G., Chaudhari Pooja S. et al. Formulation and Evaluation of Medicated candy Containing albendazole For Pediatric Indian Journal of Drugs. 2019; 7(2): 73-80. 

Recomonded Articles:

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 

Recent Articles