Author(s): Patil Karishma Ashok, Firke Sandip Dinkar

Email(s): sandipfirke@rediffmail.com

DOI: 10.5958/2231-5675.2019.00021.8   

Address: Patil Karishma Ashok1, Firke Sandip Dinkar2*
1Research Scholar, R. C. Patel Institute of Pharmaceutical Education and Research, Shipur, Dhule (425405)
2Professor, Pharmaceutical Chemistry Department, R. C. Patel Institute of Pharmaceutical Education and Research, Shipur, Dhule (425405)
*Corresponding Author

Published In:   Volume - 9,      Issue - 3,     Year - 2019


ABSTRACT:
To develop a simple, accurate, and inexpensive UV sepectrometric method for the determination of the Amodiquine hydrochloride by using quality by design (QbD) approach. The double beam spectrophotometer of Shimadzu UV-1800 by using a determination of UV spectrophotometer method. The amodiquine Hydrochloride is soluble with Distilled Water & methanol (9:1) as solvent and wavelength of 341 nm was selected as absorbance (??max). The effect to check normal variables and selected variables on spectrum characteristics were studied for the selection of critical parameters and proposed method was validated for linearity, accuracy, limits of detection and quantification as per the ICH Q2 (R1) International Conference on Harmonization guidelines. The Linearity of this method was excellent on 3 to 21 µg/mL concentration range and correlation coefficient (r2) of 0.998. The (LOD) and (LOQ) were getting found to be 0.038µg/mL and 0.084 µg/mLrespectively. The amodiquine Hydrochloride recovery was found to be 99.6%.


Cite this article:
Patil Karishma Ashok, Firke Sandip Dinkar. Determination and Development of UV-Spectrophotometric method for the Amodiquine Hydrochloride by using quality by design (QBD) approach. Asian J. Pharm. Ana. 2019; 9(3):113-117. doi: 10.5958/2231-5675.2019.00021.8


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DOI: 10.5958/2231–5675 

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