Author(s): S. Subramanya Raj Urs, Gangambika H.M., Rajashekara Murthy M., Asharani D.R.

Email(s): ssrajurs@yahoo.co.in

DOI: 10.5958/2231-5675.2020.00013.7   

Address: S. Subramanya Raj Urs, Gangambika H.M., Rajashekara Murthy M., Asharani D.R.
Post Graduate Department of Chemistry, JSS College for Women, Sarawathipuram, Mysuru 570 009
*Corresponding Author

Published In:   Volume - 10,      Issue - 2,     Year - 2020


ABSTRACT:
Present study describes development and validation of UV-Spectrophotometric method for the estimation of Atorvastatin Calcium in pharmaceutical preparation. During development of analytical methods, methanol and hydrotropic solubilization reagent is employed to enhance aqueous solubility of poorly water soluble Atovastatin Calcium in dosage forms. In the proposed methods 2M Urea and 2M Thiourea solution is used as hydrotropic solubilizing agent. Absorption maxima was determined with 10µg/ml solution by scanning in the range 200-400nm. Standard stock solution prepared in methanol (?max:247nm) and hydrotropic solubilization agent in water(?max:240nm). The proposed methods obeys Beer’s law in the range 5-40 µg/ml. The methods were validated in terms of Linearity, Precision and Accuracy. Results of analysis were validated statistically and by recovery studies. It was observed that there is no interference of impurities or excipients during the estimation of drug. This shows the adoptability of the methods for routine analysis of drugs in marketed formulations in quality control laboratories.


Cite this article:
S. Subramanya Raj Urs, Gangambika H.M., Rajashekara Murthy M., Asharani D.R. Spectrophotometric method for the estimation of Atorvastatin calcium in pharmaceutical preparation. Asian J. Pharm. Ana. 2020; 10(2):77-80. doi: 10.5958/2231-5675.2020.00013.7


Recomonded Articles:

Author(s): Santosh Gada, Anand Kumar Y, Saritha, C. Mallikarjuna Setty

DOI: 10.5958/2231-5675.2018.00036.4         Access: Open Access Read More

Author(s): Kirthi A, Shanmugam R, Mohana Lakshmi S , Ashok Kumar CK, Padmini K, Shanti Prathyusha M, Shilpa V

DOI:         Access: Open Access Read More

Author(s): Hamid Khan, Javed Ali

DOI: 10.5958/2231-5675.2017.00020.5         Access: Open Access Read More

Author(s): G. Krishnamoorthy, C. Diana Priyadarshini, R. Senthamarai

DOI:         Access: Open Access Read More

Author(s): P. Janaki Pathi, N. Appala Raju, G.Parvathalu

DOI:         Access: Open Access Read More

Author(s): Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain

DOI: 10.5958/2231-5675.2015.00025.3         Access: Open Access Read More

Author(s): Khushboo Patel*, Dhara Patel, Jaya Dwivedi, Priyanka Newal, Dhananjay Meshram

DOI: 10.5958/2231-5675.2017.00039.4         Access: Open Access Read More

Author(s): B. Thangabalan, M. Salomi, N. Sunitha, S. Manohar Babu

DOI:         Access: Open Access Read More

Author(s): Mansi J. Chaudhari, Suraj R. Chaudhari, Shailesh S. Chalikwar, Atul A. Shirkhedkar

DOI: 10.5958/2231-5675.2018.00008.X         Access: Open Access Read More

Author(s): Saroj Kumar Raul, Bukkuru Spandana, Patibandla Sameera, Vegiraju Vikitha

DOI:         Access: Open Access Read More

Author(s): S. Vidyadhara, RLC Sasidhar, B. Venkateswara Rao, P. Ratna Kumari

DOI:         Access: Open Access Read More

Author(s): Shobha Rani G, Lohita M, Jaya Preethi P, Madhavi R, Sunisitha B, Mounika D

DOI:         Access: Open Access Read More

Author(s): Madhavi R., Mohana Krishna A., Shobha Rani G., Mounika D.

DOI: 10.5958/2231-5675.2015.00008.3         Access: Open Access Read More

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 

Popular Articles


Recent Articles




Tags