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Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
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Spectrophotometric method for the estimation of Atorvastatin calcium in pharmaceutical preparation
S. Subramanya Raj Urs
Rajashekara Murthy M.
S. Subramanya Raj Urs, Gangambika H.M., Rajashekara Murthy M., Asharani D.R.
Post Graduate Department of Chemistry, JSS College for Women, Sarawathipuram, Mysuru 570 009
Present study describes development and validation of UV-Spectrophotometric method for the estimation of Atorvastatin Calcium in pharmaceutical preparation. During development of analytical methods, methanol and hydrotropic solubilization reagent is employed to enhance aqueous solubility of poorly water soluble Atovastatin Calcium in dosage forms. In the proposed methods 2M Urea and 2M Thiourea solution is used as hydrotropic solubilizing agent. Absorption maxima was determined with 10µg/ml solution by scanning in the range 200-400nm. Standard stock solution prepared in methanol (?max:247nm) and hydrotropic solubilization agent in water(?max:240nm). The proposed methods obeys Beer’s law in the range 5-40 µg/ml. The methods were validated in terms of Linearity, Precision and Accuracy. Results of analysis were validated statistically and by recovery studies. It was observed that there is no interference of impurities or excipients during the estimation of drug. This shows the adoptability of the methods for routine analysis of drugs in marketed formulations in quality control laboratories.
hydrotropic solubilization agent, Absorption maxima, Standard stock solution.
S. Subramanya Raj Urs, Gangambika H.M., Rajashekara Murthy M., Asharani D.R. Spectrophotometric method for the estimation of Atorvastatin calcium in pharmaceutical preparation. Asian J. Pharm. Ana. 2020; 10(2):77-80.
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