Author(s): R. Swetha Sri, Soundarya, K. Bhavya Sri, M. Sumakanth

Email(s): swetha.remidicharla@gmail.com

DOI: 10.52711/2231-5675.2022.00015   

Address: R. Swetha Sri1, Soundarya2, K. Bhavya Sri3, M. Sumakanth4
1Assistant Professor, Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad, India.
2Research Student, Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad, India.
3Head of the Department, Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad, India.
4Head of the Institution, Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2022


ABSTRACT:
A Simple and precise UV-spectroscopic method was developed for the determination of Imatinib Mesylate in its bulk and formulation. The developed method has been validated for various parameters like specificity, accuracy, linearity, robustness according to USP general chapter<1225> and ICH Q2R1 guidelines. Pure solution of Imatinib Mesylate was scanned in the whole range of UV region where it has shown the maximum absorbance at 258nm. The RSD values for method precision and intermediate precision were found to be well within the acceptance criteria and the series of dilutions were found to be linear (2-12ug/ml) where r2= 0.999 was the regression value. Limit of detection (0.2925µg/ml) and Limit of quantification (0.8977µg/ml) of IMT were established. Further, the drug has been subjected to various stress conditions, and percent degraded was reported. Drug solutions have shown stability on the benchtop for up to 8 hours and 72 hours when the solutions were refrigerated.


Cite this article:
R. Swetha Sri, Soundarya, K. Bhavya Sri, M. Sumakanth. Stability Indicating UV-Spectrophotometric Method Development and its Validation for the Determination of Imatinib Mesylate in Bulk and Formulation. Asian Journal of Pharmaceutical Analysis. 2022; 12(2):83-6. doi: 10.52711/2231-5675.2022.00015

Cite(Electronic):
R. Swetha Sri, Soundarya, K. Bhavya Sri, M. Sumakanth. Stability Indicating UV-Spectrophotometric Method Development and its Validation for the Determination of Imatinib Mesylate in Bulk and Formulation. Asian Journal of Pharmaceutical Analysis. 2022; 12(2):83-6. doi: 10.52711/2231-5675.2022.00015   Available on: https://ajpaonline.com/AbstractView.aspx?PID=2022-12-2-3


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