Author(s):
Pranali Dhapodkar, Anjali Ganjare, Kalyani Lanjewar, Pranita Rathod, Shweta Nawghare
Email(s):
pranali.dhapodkar@raisoni.net , anjali.ganjare@raisoni.net , kalyanithombre22271994@gmail.com , pranita.rathod@raisoni.net , shweta.nawghare@raisoni.net
DOI:
10.52711/2231-5675.2025.00028
Address:
Pranali Dhapodkar1*, Anjali Ganjare1, Kalyani Lanjewar2, Pranita Rathod1, Shweta Nawghare1
1Associate Professor, G H Raisoni Institute of Pharmacy, Nagpur, Maharashtra, India.
2Assistant Professor, G H Raisoni Institute of Pharmacy, Nagpur, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 3,
Year - 2024
ABSTRACT:
Antimicrobial drugs are the greatest contribution to the 20th century to therapeutics. The methodology indicates and characterizes various aspects like melting point, solubility, TLC, and IR. The experimental work comprises of various methods like preparation of 2-amino-5-trifluromethyl,1,3,4, thiadiazole preparation. According to this, we synthesized a series of sixteen derivatives of selected compound. The synthesized compounds were evaluated for antimicrobial and antifungal activity by disc diffusion method. The results of the antimicrobial screening studies clearly shows moderate to mild antimicrobial activity.
Cite this article:
Pranali Dhapodkar, Anjali Ganjare, Kalyani Lanjewar, Pranita Rathod, Shweta Nawghare. Synthesis, Antifungal and Anti-Tubercular Activity Evaluation of Series of Imidazo [2,1-b]1,3,4-Thiadiazole Derivatives. Asian Journal of Pharmaceutical Analysis. 2025; 15(3):181-4. doi: 10.52711/2231-5675.2025.00028
Cite(Electronic):
Pranali Dhapodkar, Anjali Ganjare, Kalyani Lanjewar, Pranita Rathod, Shweta Nawghare. Synthesis, Antifungal and Anti-Tubercular Activity Evaluation of Series of Imidazo [2,1-b]1,3,4-Thiadiazole Derivatives. Asian Journal of Pharmaceutical Analysis. 2025; 15(3):181-4. doi: 10.52711/2231-5675.2025.00028 Available on: https://ajpaonline.com/AbstractView.aspx?PID=2024-15-3-4
REFERENCES:
1. www.textbookofbacteriology.net/antimicrobials Chambers H.F. General Principles of Chemotherapy. The Pharmacological Basis of Therapeutics. Goodman Gilman 11th Edition 2004, 1095-1124
2. Tripathi KD. Essential of Medicinal Pharmacology, 5th ed. Jaypee Brothers, New Delhi
3. Kadam SS, Mahadik KR, Bothara KG. Principles of Medicinal Chemistry Vol-I.
4. Vogel AI. Text Book of Practical Organic Chemistry, 4th ed. Elbs and Long Mann London.
5. http://en.wikipedia.org/wiki/Quinolone#cite_note-67.
6. Chung-Kyu Ryu, Ju-Yeon Shim, Mi Jin Chae, Ik Hwa Choi, Ja-Young Han, Ok-Jai Jung, JungYoon Lee, Seong Hee Jeong. Synthesis and antifungal activity of 2/3-arylthio and 2,3-bis(arylthio)-5-hydroxy-/5-methoxy-1,4-naphthoquinones. Eur. J. Med.Chem. 2005; 40: 438–444.
7. National Committee for Clinical Laboratory Standards, Reference Method for Broth Dilution Antifungal Susceptibility Testing for Yeasts. Approval Standard. Document M27-A. National Committee for Clinical Laboratory Standards, Wayne, PA, 1997.
8. National Committee for Clinical Laboratory Standards (NCCLS), Methods for Broth Dilution Antifungal Susceptibility Testing of Conidium Forming Filamentous Fungi. Proposed Standard (M38-P), National Committee for Clinical Laboratory Standards, Wayne, PA, 1998.
9. Mallikarjuna BP, Sastry BS, Suresh Kumar GV, Rajendraprasad Y, Chandrashekar SM, Sathisha K. Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems-A novel class of potential antibacterial, antifungal and antitubercular agents. Eur. J. Med.Chem. 2009; 44: 4739–4746
10. Hearn M.J, PCT Int. Appl.WO 02043668, 2002; Chem. Abstr. 2002; 137: 20296.
11. R.R. Shah, R.D. Mehta, A.R. Parikh. J. Indian Chem. Soc.1985; 62: 255–260.
12. S. Goto, K. Jo, T. Kawakita, S. Misuhashi, T. Nishino, N. Ohasawa, H. Tanami. Chemotherapy.1981; 29: 76–79.