Author(s): Tasneem O. ElmahadiI, Shaza W. A Shantier, Mohamed E. Adam

Email(s): adamo86073@gmail.com

DOI: 10.5958/2231-5675.2019.00004.8   

Address: Tasneem O. ElmahadiI2, Shaza W. A Shantier1 and Mohamed E. Adam1*
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Sudan
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omdurman Islamic University Omdurman, Sudan
*Corresponding Author

Published In:   Volume - 9,      Issue - 1,     Year - 2019


ABSTRACT:
Simple, sensitive and accurate spectrophotometric method was developed for the estimation of Enrofloxacin (EFC) in bulk and injection dosage form. The method was based on the measurement of EFC solution in 0.1M potassium hydroxide at 271nm. Validation was conducted in accordance to ICH guidelines. The developed method was found to be linear in the concentration range 2-10 µg/ml (r= 0.999), sensitive (LOD was found 0.127 µg/ml) and precise (RSD% values are less than 2%). Freedom from interference by the formulation excipients was proved by the good recovery percentages’ results (100.06% ± 1.12, n=3). The proposed method was successfully used to estimate EFC in laboratory mixture and in the injection dosage forms.


Cite this article:
Tasneem O. ElmahadiI, Shaza W. A Shantier, Mohamed E. Adam. Development and Validation of UV–Spectrophotometric method for the Determination of Enrofloxacin in Synthetic form and Veterinary Injectible Dosage forms. Asian J. Pharm. Ana. 2019; 9(1):11-14. doi: 10.5958/2231-5675.2019.00004.8


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Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

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DOI: 10.5958/2231–5675 

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