Author(s):
M Venkataramana, P. Sankeerthana, Ganesh Akula, Yerrolla Soundarya, Salla Pujitha
Email(s):
m_ramana100@yahoo.com
DOI:
10.52711/2231-5675.2026.00029 
Address:
M Venkataramana1*, P. Sankeerthana1, Ganesh Akula1, Yerrolla Soundarya1, Salla Pujitha2
1Department of Pharmaceutical Analysis, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India.
2Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 3,
Year - 2026
ABSTRACT:
A simple, accurate, and reliable Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) method was developed and validated for the simultaneous estimation of Meloxicam and Paracetamol in bulk and pharmaceutical dosage forms. The chromatographic analysis was carried out using a Waters HPLC system equipped with an auto sampler and PDA detector (Model 996). Separation was achieved on a Zodiac C18 column (4.6mm × 150mm, 5µm) maintained at a temperature of 38°C. The mobile phase consisted of Acetonitrile and Water in the ratio of 40:60v/v, delivered at a flow rate of 1.0mL/min. Detection was performed at a wavelength of 223nm, with a 10µL injection volume and a run time of 10minutes. The method provided effective resolution of Meloxicam and Paracetamol with sharp and well-defined peaks. Validation of the method was performed according to ICH guidelines, and the method was found to be linear, precise, accurate, robust, and specific. The results confirm that the developed RP-HPLC method is suitable for routine quality control analysis of Meloxicam and Paracetamol in combined pharmaceutical formulations.
Cite this article:
M Venkataramana, P. Sankeerthana, Ganesh Akula, Yerrolla Soundarya, Salla Pujitha. Method Development and Validation of RP-HPLC Method for Determination of Meloxicam and Paracetamol in Bulk and Pharmaceutical Formulation. Asian Journal of Pharmaceutical Analysis. 2026; 16(3):191-6. doi: 10.52711/2231-5675.2026.00029
Cite(Electronic):
M Venkataramana, P. Sankeerthana, Ganesh Akula, Yerrolla Soundarya, Salla Pujitha. Method Development and Validation of RP-HPLC Method for Determination of Meloxicam and Paracetamol in Bulk and Pharmaceutical Formulation. Asian Journal of Pharmaceutical Analysis. 2026; 16(3):191-6. doi: 10.52711/2231-5675.2026.00029 Available on: https://ajpaonline.com/AbstractView.aspx?PID=2026-16-3-5
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