Author(s):
K.Y. Kavitha, A. Saravanakumar, P. Parthiban, B. Periyanayaki
Email(s):
kavirajangobi@gmail.com
DOI:
10.52711/2231-5675.2026.00030 
Address:
K.Y. Kavitha1*, A. Saravanakumar2, P. Parthiban3, B. Periyanayaki4
1Professor, Department of Pharmaceutical Analysis, Vellalar College of Pharmacy, Maruthi Nagar, Thindal, Erode - 638012, Tamilnadu, India.
2Principal, Department of Pharmaceutical Biotechnology, Vellalar College of Pharmacу, Maruthi Nagar, Thindal, Erode - 638012, Tamilnadu, India.
3Vice Principal, Department of Pharmaceutical Chemistry, Vellalar College of Pharmacу, Maruthi Nagar, Thindal, Erode - 638012, Tamilnadu, India.
4Student, Department of Pharmaceutical Analysis, Vellalar College of Pharmacy, Maruthi Nagar, Thindal, Erode - 638012, Tamilnadu, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 3,
Year - 2026
ABSTRACT:
In the treatment of respiratory conditions, acebrophylline, a xanthine derivative with mucoregulatory and anti-inflammatory qualities, is frequently used in fixed-dose formulations with antihistamines and leukotriene receptor antagonists. Accurate, precise and stability-indicating analytical techniques are required for the quantification of Acebrophylline in pharmaceutical dosage forms and bulk medications due to its expanding therapeutic application. This study provides a thorough summary of the published analytical methods for acebrophylline, such as UV spectrophotometric, HPTLC, RP-HPLC and UHPLC procedures. ICH-compliant validation parameters, chromatographic conditions, detection wavelengths, stability-indicating capabilities and method development methodologies are all prioritized. A comparative analysis of the methodologies presented reveals the strengths and weaknesses of each approach with respect to run time, sensitivity, specificity and suitability for combination formulations. The review also highlights future opportunities and existing limitations such as the need for enhanced deterioration profiles, sophisticated detection systems and green analytical techniques. For researchers and quality control analysts working on pharmaceutical analyses of Acebrophylline and related combination products, this review offers a comprehensive resource.
Cite this article:
K.Y. Kavitha, A. Saravanakumar, P. Parthiban, B. Periyanayaki. Analytical Insights into Acebrophylline: Advances in Method Development and Validation. Asian Journal of Pharmaceutical Analysis. 2026; 16(3):197-3. doi: 10.52711/2231-5675.2026.00030
Cite(Electronic):
K.Y. Kavitha, A. Saravanakumar, P. Parthiban, B. Periyanayaki. Analytical Insights into Acebrophylline: Advances in Method Development and Validation. Asian Journal of Pharmaceutical Analysis. 2026; 16(3):197-3. doi: 10.52711/2231-5675.2026.00030 Available on: https://ajpaonline.com/AbstractView.aspx?PID=2026-16-3-6
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