ABSTRACT:
Levofloxacin is a fluoroquinolone antibacterial medicine with broad spectrum of activity. It is effective against respiratory, urinary, and soft tissue infections. In order to assure therapeutic efficacy and safety of this drug, reliable methods are required for quantitative determination of levofloxacin in pharmaceutical preparations and in biological samples. In this paper, the mechanisms of action of levofloxacin and the recently developed methods for determination of this compound are discussed. Methods based on UV–visible spectrophotometry, high-performance liquid chromatography, liquid chromatography-mass spectrometry, and high-performance thin-layer chromatography are considered. A special attention is given to method development and validation parameters such as accuracy, precision, specificity, and robustness. Additionally, stability-indicating methods for determination of levofloxacin are presented. This review is intended to provide a comprehensive overview of currently available methods for determination of levofloxacin that can be useful for scientists and quality control analysts working in pharmaceutical industries.
Cite this article:
Prachi Rajesh Patil, Javesh K. Patil. A Comprehensive Review on Analytical Strategies for the Determination of Levofloxacin in Single Dosage Forms. Asian Journal of Pharmaceutical Analysis. 2026; 16(3):224-8. doi: 10.52711/2231-5675.2026.00034
Cite(Electronic):
Prachi Rajesh Patil, Javesh K. Patil. A Comprehensive Review on Analytical Strategies for the Determination of Levofloxacin in Single Dosage Forms. Asian Journal of Pharmaceutical Analysis. 2026; 16(3):224-8. doi: 10.52711/2231-5675.2026.00034 Available on: https://ajpaonline.com/AbstractView.aspx?PID=2026-16-3-10
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