Author(s): Priyanka P. Atodariya, Hasumati A. Raj, Vineet C. Jain

Email(s): atodariya.priyanka@yahoo.com , drharaj@yahoo.com

DOI: 10.5958/2231-5675.2015.00013.7   

Address: Priyanka P. Atodariya*, Hasumati A. Raj, Vineet C. Jain
Shree Dhanvantary Pharmacy Collage Kim, Surat, Gujarat, India
*Corresponding Author

Published In:   Volume - 5,      Issue - 2,     Year - 2015


ABSTRACT:
Two simple spectroscopic methods have been developed for simultaneous estimation of Lamotrigine and Clozapine in synthetic mixture. Simultaneous equation method involves the measurement of absorption at two wavelengths 308 nm (?max for Lamotrigine) and 259.60 nm (?max for Clozapine). The method was found linear between the range of 1-5 µg/ml for Lamotrigine and 6-30 µg/ml for Clozapine for method .The accuracy and precision was determined and validated statistically. Both the method showed good reproducibility and recovery with %RSD less than 1.The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis for Lamotrigine and Clozapine in bulk and combined dosage form.


Cite this article:
Priyanka P. Atodariya, Hasumati A. Raj, Vineet C. Jain. Simultaneous Estimation of Lamotrigine and Clozapine by Simultaneous equation method in their Synthetic Mixture which use in Schizophrenia. Asian J. Pharm. Ana. 5(2): April-June 2015; Page 79-85. doi: 10.5958/2231-5675.2015.00013.7


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Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

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DOI: 10.5958/2231–5675 

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