Author(s): Swapnil D. Jadhav, Akshay A. Magdum, Ramchandra M. Panchal, Pradip S. Koli

Email(s): swapnil.jadhav@bharatividyapeeth.edu

DOI: Not Available

Address: Swapnil D. Jadhav*, Akshay A. Magdum, Ramchandra M. Panchal and Pradip S. Koli
Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur – 416013.
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2013


ABSTRACT:
Metformin HCl (MET) and Rosiglitazone Maleate (ROS) are used in combination for treatment of diabetes as both drugs are oral hypoglycemic gents. The present work deals with simple derivative spectrophotometric method development for simultaneous estimation of MET and ROS in tablet formulation (AVANDAMET). For determination of sampling wavelength, 10 µg/ml of each of MET and ROS were scanned on UV-630 double beam spectrophotometer in 200-400 nm range. The estimation of ROS was carried out at 312 nm in zero order mode where MET showed zero crossing point and MET was estimated at 247 nm in first order mode where ROS showed zero crossing point. The marketed tablet formulation contains 500 mg of MET and 4 mg of ROS. Hence for analysis of ROS, standard addition of 100 mg of pure drug is carried out. For this method, linearity was observed in range of 10-90 µg/ml for MET and 2-18 µg/ml for ROS. The method is validated as per ICH guidelines. The recovery studies confirmed accuracy of proposed method and low values of standard deviation confirmed precision of method. The proposed method can be optimized further for the simultaneous estimation of both drugs from biological fluids, used in pharmacokinetic and bioequivalence studies.


Cite this article:
Swapnil D. Jadhav, Akshay A. Magdum, Ramchandra M. Panchal , Pradip S. Koli. Simultaneous Estimation of Metformin Hydrochloride and Rosiglitazone Maleate from Tablet Dosage Form by Derivative Spectroscopic Method. Asian J. Pharm. Ana. 3(3): July-Sept. 2013; Page 94-97.


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