Formulation and Evaluation of Herbal Anticancer Chewing Gum

Vaishnavi S. Honale; Shraddha D. Muneshwar; Sohan S. Thipe; Amol V. Sawale

doi:10.52711/2231-5675.2023.00046

Asian Journal of Pharmaceutical Analysis

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2231-5675 (Online)
2231-5667 (Print)

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Formulation and Evaluation of Herbal Anticancer Chewing Gum

Author(s): Vaishnavi S. Honale, Shraddha D. Muneshwar, Sohan S. Thipe, Amol V. Sawale

Email(s): vaishnavihonale2000@gmail.com

DOI: 10.52711/2231-5675.2023.00046

Address: Vaishnavi S. Honale*, Shraddha D. Muneshwar, Sohan S. Thipe, Amol V. Sawale
Vidyabharati College of Pharmacy, Naidu Marg, Camp, Amravati – 444602.
*Corresponding Author

Published In: Volume - 13, Issue - 4, Year - 2023

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ABSTRACT:
The objective of the present study is the formulation and evaluation of herbal anticancer Chewing gum. Cancer is the abnormal growth of cells in the body. With emerging trends in herbal medicine and complementary alternative medicine, India is considered one of the world's largest producers of herbal medicine. Many plants and their products have anticancer agents. Ginger is considered an important spice with many clinical potential activities. Ginger and its compounds display anti-inflammatory, antioxidant, antimetastatic, and anticancer activity. The anticancer activity of ginger components is reviewed in this article due to its versatile therapeutic nature. The medicated chewing gum of gingerol was prepared by direct compression mold method. Five formulations were selected for study which was showing good physicochemical properties and drug release. Formulations were characterized for physical evaluation, weight variation, stickiness, hardness/plasticity, in vitro drug release, estimation of chewing gum consistency, and drug release study in saliva. All the formulations showed satisfactory results in physical evaluation, weight variation, stickiness, and hardness. The formulation medicated chewing gum 2 (F2 Batch) showed the best in-vitro drug release of 96% in 30 min and it is also accepted by people. Drug release in saliva also indicated that more than 50% of drug release occurs within 15 min. Medicated Chewing Gum is cost-effective and also shows better compliance with an increase in bioavailability.

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Cite this article:
Vaishnavi S. Honale, Shraddha D. Muneshwar, Sohan S. Thipe, Amol V. Sawale. Formulation and Evaluation of Herbal Anticancer Chewing Gum. Asian Journal of Pharmaceutical Analysis. 2023; 13(4):278-4. doi: 10.52711/2231-5675.2023.00046

Cite(Electronic):
Vaishnavi S. Honale, Shraddha D. Muneshwar, Sohan S. Thipe, Amol V. Sawale. Formulation and Evaluation of Herbal Anticancer Chewing Gum. Asian Journal of Pharmaceutical Analysis. 2023; 13(4):278-4. doi: 10.52711/2231-5675.2023.00046 Available on: https://ajpaonline.com/AbstractView.aspx?PID=2023-13-4-10

REFERENCES:
1.   Yogita R. Indalkar, Nayana V. Pimpodkar, Anita S. Godase, Puja S. Gaikwad. A Compressive Review on the Study of Nanotechnology for Herbal Drugs. Asian Journal of Pharmaceutical Research. 2015; 5(4):203-207.
2.   Devangamath BG, Raddi SA. A Randomized Control Trial to Assess the Efficacy of Dry Ginger Powder on Management of Nausea and Vomiting Among Antenatal Mothers Attending Selected Urban Health Centres of Belgaum, Karnataka – One Group Pretest Post Test Pre Experimental Study. Asian Journal of Nursing Education and Research. 2016; 6(1):17-26.
3.   P. Padmavathi, Raja Sankar, N. Kokilavani. A Study to Assess the Effectiveness of Ginger Powder on Dysmenorrhoea among Adolescents in a Selected School at Erode. Asian Journal of Nursing Education and Research. 2012; 2(2):79-82.
4.   Firdous N. et al. Optimization of Drying Conditions to Preserve Gingerol in Ginger. Acta Scientific Agriculture. 2021; 5(7):38-43.
5.   Prasad S., Tyagi AK. Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer. Gastroenterology Research and Practice. 2015; 142979.
6.   Juno S. et al. A Review on Medicated Chewing Gum. Indo American Journal of Pharmaceutical Sciences. 2019; 06(11): 14725-14733.
7.   Ahmed Mohammed Elamin Osman. et al. In-vitro Anticancer and Cytotoxic Activity of Ginger Extract on Human Breast Cell Lines. 2020; 26-29.
8.   Neeru Bhatt. Et al. Ginger: A functional Herb. Nova Science Publishers. 2013; 51-72.
9.   Ranjani Ramakrishnan. et al. Anticancer Properties of Zingiber Officinale - Ginger: A review. International Journal of Medicine and Pharmaceutical Sciences. 2013; 3(5):11-20.
10.   Dr Gaikwad DD. et al. Isolation and standardization of gingerol from ginger rhizome by using TLC, HPLC, and identification tests. The Pharma Innovation. 2017; 6(2):179-182
11.   Lall Dipesh, et al. Formulation and evaluation of new medicated chewing gum for the treatment of nausea and vomiting induced by chemotherapy, radiation therapy and post operative conditions in cancer. Asian Journal of Pharmaceutical and Clinical Research. 2020; 13(4):157-160
12.   P.S. Salve. Development and in vitro evaluation colon targeted drug delivery system using natural gums. Asian Journal of Pharmaceutical Research. 2011; 1(4):91-101.
13.   Shete et al. Formulation of eco-friendly medicated chewing gum to prevent motion sickness. AAPS Pharm Sci Tech. 2015; 16(5): 1041-1050
14.   Aslani A. et al. Design, formulation and evaluation of ginger medicated chewing gum. Advanced Biomedical Research. 2016; 5(1)
15.   Abolfazi Aslami. et al. Formulation and Evaluation of medicinal chewing gum by the extract of Salvadora Persica L. Life Science Journal. 2013; 10(4s):47-55.
16.   S. J. Daharwal, Veena Devi Thakur, Shikha Shrivastava, Bhanu Pratap Sahu. Designing and Optimization of Modified Dissolution Apparatus for Evaluation of Medicated Chewing Gum of Ambroxol HCl. Asian Journal of Pharmaceutical Research. 2013; 3(3):141-143.

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