Author(s): A. S. Sutar, M. B. Mangsule

Email(s): abhijitsutar@gmail.com

DOI: 10.52711/2231-5675.2022.00037   

Address: A. S. Sutar*, M. B. Mangsule
School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Pune - 411038, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 4,     Year - 2022


ABSTRACT:
Two chemometric methods PLS and PCR were used to simultaneously estimate Ofloxacin and Ornidazole in binary mixtures. Mean centering is used as a preprocessing tool and then PLS and PCR models were built with help of calibration and validation set. These methods showed good results for validation parameters including accuracy, precision, linearity, robustness etc. at the same time lower values of RMSEP, PRESS and RMSECV shows statistical significance of the developed methods. Results show that multivariate calibrations techniques can be successfully used to analyses Ofloxacin and Ornidazole in pharmaceutical formulations.


Cite this article:
A. S. Sutar, M. B. Mangsule. Application of PLS and PCR as Multivariate Calibration Techniques for Simultaneous Estimation of Ofloxacin and Ornidazole in Binary Mixtures. Asian Journal of Pharmaceutical Analysis. 2022; 12(4):228-2. doi: 10.52711/2231-5675.2022.00037

Cite(Electronic):
A. S. Sutar, M. B. Mangsule. Application of PLS and PCR as Multivariate Calibration Techniques for Simultaneous Estimation of Ofloxacin and Ornidazole in Binary Mixtures. Asian Journal of Pharmaceutical Analysis. 2022; 12(4):228-2. doi: 10.52711/2231-5675.2022.00037   Available on: https://ajpaonline.com/AbstractView.aspx?PID=2022-12-4-2


REFERENCES:
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2.    P. V. Rege and P. A. Sathe, simultaneous quantification of ofloxacin and ornidazole in combined drug formulation by a simple electro-analytical technique. IJPSR, 2011; Vol. 2(8): 2226-2231.
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