Author(s):
Shivani Sharma, Navdeep Singh, Amar Deep Ankalgi, Arti Rana, Mahendra Singh Ashawat
Email(s):
navdeepsingh23.ns@gmail.com
DOI:
10.52711/2231-5675.2021.00042
Address:
Shivani Sharma, Navdeep Singh*, Amar Deep Ankalgi, Arti Rana, Mahendra Singh Ashawat
Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India.
*Corresponding Author
Published In:
Volume - 11,
Issue - 3,
Year - 2021
ABSTRACT:
Direct real time analysis (DART) is the most successful tool for the analysis of the compounds. This technique is useful for the identification, and classification of compounds. It is widely followed by the forensic chemistry, and also used for many purposes. Their main applications include inks, paints, drugs, bank dyes, explosives, beverages, and gunshot etc. The basic concepts of DART-MS were highlighted to understand the process. Also the basic fundamentals of DART-MS including special function were discussed. Various natural products were discovered by DART-MS includes plant tissue, insects, and microbe etc. The main focus of this review article is on the applications of direct real time analysis, which covers the varieties of uses in our pharmaceutical as well as chemical industries. This technique was helpful in the production of food material, and to identify the contaminants from animal sources in the part of veterinary drugs. Also, used in food processing in the form of additives, and adulterants. DART-MS has huge applications on analysis of seized drug like steroids supplements, psychoactive plants etc. Also, in inks, paint, and documents industry this technique has been widely used. So, this review covers the basic fundamentals of direct real time analysis DART-MS, and their applications.
Cite this article:
Shivani Sharma, Navdeep Singh, Amar Deep Ankalgi, Arti Rana, Mahendra Singh Ashawat. A Precise Review on Applications and Basic Concept of Direct Analysis in Real Time Mass Spectrometry (DART-MS). Asian Journal of Pharmaceutical Analysis. 2021; 11(3):243-1. doi: 10.52711/2231-5675.2021.00042
Cite(Electronic):
Shivani Sharma, Navdeep Singh, Amar Deep Ankalgi, Arti Rana, Mahendra Singh Ashawat. A Precise Review on Applications and Basic Concept of Direct Analysis in Real Time Mass Spectrometry (DART-MS). Asian Journal of Pharmaceutical Analysis. 2021; 11(3):243-1. doi: 10.52711/2231-5675.2021.00042 Available on: https://ajpaonline.com/AbstractView.aspx?PID=2021-11-3-12
REFERENCES:
1. Cody RB, Laramée JA, Durst HD. Versatile new ion source for the analysis of materials in open air under ambient conditions. Analytical Chemistry. 2005; 77(8): 2297-302.
2. Takáts Z, Wiseman JM, Gologan B, Cooks RG. Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science. 2004; 306(5695): 471-3.
3. Weston DJ. Ambient ionization mass spectrometry: current understanding of mechanistic theory; analytical performance and application areas. Analyst. 2010; 135(4): 661-8.
4. Venter A, Nefliu M, Cooks RG. Ambient desorption ionization mass spectrometry. TrAC Trends in Analytical Chemistry. 2008; 27(4): 284-90.
5. Singh N, Sondhi S, Jindal S, Pandit V, Ashawat MS. Treatment and Management for patients with mild to severe Psoriasis: A Review. Asian Journal of Pharmaceutical Research. 2020; 10(4): 286-92.
6. Green FM, Salter TL, Stokes P, Gilmore IS, O'Connor G. Ambient mass spectrometry: advances and applications in forensics. Surface and Interface Analysis: An International Journal devoted to the development and application of techniques for the analysis of surfaces, interfaces and thin films. 2010; 42(5): 347-57.
7. Kusai A. Fundamental and application of the direct analysis in real time mass spectrometry. Bunseki. 2007; 3: 124-7.
8. Saitoh K. Direct analysis for fragrance ingredients using DART-TOFMS. Aroma Res. 2007; 8(4): 366-9.
9. Konuma K. Elementary guide to ionization methods for mass spectrometry: introduction of the direct analysis in real time mass spectrometry. Bunseki. 2009; 9: 464-7.
10. Kikura-Hanajiri R. Simple and rapid screening for target compounds using direct analysis in real time (DART)-MS. Foods Food Ingred J Japan. 2010; 215: 137-43.
11. Chernetsova ES, Morlock GE. Mass spectrometric method of direct sample analysis in real time (DART) and application of the method to pharmaceutical and biological analysis. Zavod Lab Diagn Mater. 2011; 77: 10-9.
12. Singh N, Goyal K, Sondhi S, Jindal S. Traditional and medicinal use of Barbaloin: potential for the management of various diseases. Journal of Applied Pharmaceutical Research. 2020; 8(3): 21-30.
13. Chernetsova ES, Morlock GE, Revelsky IA. DART mass spectrometry and its applications in chemical analysis. Russian Chemical Reviews. 2011; 80(3): 235.
14. Osuga J, Konuma K. Applications of direct analysis in real time (DART) mass spectrometry. Journal of Synthetic Organic Chemistry Japan. 2011; 69(2): 171-5.
15. Cooks RG, Ouyang Z, Takats Z, Wiseman JM. Ambient mass spectrometry. Science. 2006; 311(5767): 1566-70.
16. Dzidic I, Carroll DI, Stillwell RN, Horning EC. Comparison of positive ions formed in nickel-63 and corona discharge ion sources using nitrogen, argon, isobutane, ammonia and nitric oxide as reagents in atmospheric pressure ionization mass spectrometry. Analytical Chemistry. 1976; 48(12): 1763-8.
17. Carroll DI, Dzidic I, Stillwell RN, Haegele KD, Horning EC. Atmospheric pressure ionization mass spectrometry. Corona discharge ion source for use in a liquid chromatograph-mass spectrometer-computer analytical system. Analytical Chemistry. 1975; 47(14): 2369-73.
18. Rummel JL, McKenna AM, Marshall AG, Eyler JR, Powell DH. The coupling of direct analysis in real time ionization to Fourier transform ion cyclotron resonance mass spectrometry for ultrahigh‐resolution mass analysis. Rapid Communications in Mass Spectrometry. 2010; 24(6): 784-90.
19. Robb DB, Covey TR, Bruins AP. Atmospheric pressure photoionization: an ionization method for liquid chromatography− mass spectrometry. Analytical Chemistry. 2000; 72(15): 3653-9.
20. Chen H, Ouyang Z, Cooks RG. Thermal production and reactions of organic ions at atmospheric pressure. Angewandte Chemie. 2006; 118(22): 3738-42.
21. Peng WP, Goodwin MP, Chen H, Cooks RG, Wilker J. Thermal formation of mixed‐metal inorganic complexes at atmospheric pressure. Rapid Communications in Mass Spectrometry. 2008; 22(22): 3540-8.
22. Singh N, Goyal K, Sondhi S, Jindal S. Development and Characterization of Barbaloin Gel for the Safe and Effective Treatment of Psoriasis. Journal of Drug Delivery and Therapeutics. 2020; 10(5): 188-97.
23. Hiraoka K, Ninomiya S, Chen LC, Iwama T, Mandal MK, Suzuki H, Ariyada O, Furuya H, Takekawa K. Development of double cylindrical dielectric barrier discharge ion source. Analyst. 2011; 136(6): 1210-5.
24. Andrade FJ, Shelley JT, Wetzel WC, Webb MR, Gamez G, Ray SJ, Hieftje GM. Atmospheric pressure chemical ionization source. 1. Ionization of compounds in the gas phase. Analytical Chemistry. 2008; 80(8): 2646-53.
25. Cody RB. Observation of molecular ions and analysis of nonpolar compounds with the direct analysis in real time ion source. Analytical Chemistry. 2009; 81(3): 1101-7.
26. Furuya H, Kambara S, Nishidate K, Fujimaki S, Hashimoto Y, Suzuki S, Iwama T, Hiraoka K. Quantitative aspects of atmospheric-pressure Penning ionization. Journal of the Mass Spectrometry Society of Japan. 2010; 58(6): 211-3.
27. Yew JY. Natural product discovery by direct analysis in real time mass spectrometry. Mass Spectrometry. 2019: S0081.
28. Song L, Dykstra AB, Yao H, Bartmess JE. Ionization mechanism of negative ion-direct analysis in real time: a comparative study with negative ion-atmospheric pressure photoionization. Journal of the American Society for Mass Spectrometry. 2009; 20(1): 42-50.
29. Dane AJ, Cody RB. Selective ionization of melamine in powdered milk by using argon direct analysis in real time (DART) mass spectrometry. Analyst. 2010; 135(4): 696-9.
30. Yang H, Wan D, Song F, Liu Z, Liu S. Argon direct analysis in real time mass spectrometry in conjunction with makeup solvents: a method for analysis of labile compounds. Analytical Chemistry. 2013; 85(3):1305-9.
31. Haunschmidt M, Klampfl CW, Buchberger W, Hertsens R. Rapid identification of stabilisers in polypropylene using time-of-flight mass spectrometry and DART as ion source. Analyst. 2010; 135(1): 80-5.
32. Vaclavik L, Cajka T, Hrbek V, Hajslova J. Ambient mass spectrometry employing direct analysis in real time (DART) ion source for olive oil quality and authenticity assessment. Analytica Chimica Acta. 2009; 645(1-2): 56-63.
33. McEwen CN, Larsen BS. Ionization mechanisms related to negative ion APPI, APCI, and DART. Journal of the American Society for Mass Spectrometry. 2009; 20(8):1518-21.
34. Tsuchiya M, Taira T. A New Ionization Method for Organic Compounds.-Liquid Ionization at Atmospheric Pressure Utilizing Penning Effect and Chemical Ionization. Journal of the Mass Spectrometry Society of Japan. 1978; 26(4): 333-42.
35. Faubert D, Paul GJ, Giroux J, Bertrand MJ. Selective fragmentation and ionization of organic compounds using an energy-tunable rare-gas metastable beam source. International journal of mass spectrometry and ion processes. 1993; 124(1): 69-77.
36. Andrade FJ, Shelley JT, Wetzel WC, Webb MR, Gamez G, Ray SJ, Hieftje GM. Atmospheric pressure chemical ionization source. 1. Ionization of compounds in the gas phase. Analytical Chemistry. 2008; 80(8): 2646-53.
37. Gilbert-López B, García-Reyes JF, Meyer C, Michels A, Franzke J, Molina-Díaz A, Hayen H. Simultaneous testing of multiclass organic contaminants in food and environment by liquid chromatography/dielectric barrier discharge ionization-mass spectrometry. Analyst. 2012; 137(22): 5403-10.
38. Tolmachev AV, Chernushevich IV, Dodonov AF, Standing KG. A collisional focusing ion guide for coupling an atmospheric pressure ion source to a mass spectrometer. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 1997; 124(1): 112-9.
39. Gilbert-López B, Schilling M, Ahlmann N, Michels A, Hayen H, Molina-Díaz A, García-Reyes JF, Franzke J. Ambient diode laser desorption dielectric barrier discharge ionization mass spectrometry of nonvolatile chemicals. Analytical Chemistry. 2013; 85(6): 3174-82.
40. Harris GA, Fernández FM. Simulations and experimental investigation of atmospheric transport in an ambient metastable-induced chemical ionization source. Analytical Chemistry. 2009; 81(1): 322-9.
41. Kuki Á, Nagy L, Zsuga M, Kéki S. Fast identification of phthalic acid esters in poly (vinyl chloride) samples by direct analysis in real time (DART) tandem mass spectrometry. International Journal of Mass Spectrometry. 2011; 303(2-3): 225-8.
42. Maldonado-Torres M, López-Hernández JF, Jiménez-Sandoval P, Winkler R. ‘Plug and Play’assembly of a low-temperature plasma ionization mass spectrometry imaging (LTP-MSI) system. Journal of Proteomics. 2014; 102: 60-5.
43. Marshall AG, Hendrickson CL. High-resolution mass spectrometers. Annu. Rev. Anal. Chem.. 2008; 1: 579-99.
44. Luosujärvi L, Kanerva S, Saarela V, Franssila S, Kostiainen R, Kotiaho T, Kauppila TJ. Environmental and food analysis by desorption atmospheric pressure photoionization‐mass spectrometry. Rapid Communications in Mass Spectrometry: An International Journal Devoted to the Rapid Dissemination of Up‐to‐the‐Minute Research in Mass Spectrometry. 2010; 24(9): 1343-50.
45. Reeber SL, Gadi S, Huang SB, Glish GL. Direct analysis of herbicides by paper spray ionization mass spectrometry. Analytical Methods. 2015; 7(23): 9808-16.
46. Kern SE, Lin LA, Fricke FL. Accurate mass fragment library for rapid analysis of pesticides on produce using ambient pressure desorption ionization with high-resolution mass spectrometry. Journal of the American Society for Mass Spectrometry. 2014; 25(8): 1482-8.
47. Self RL, Wu WH. Rapid qualitative analysis of phthalates added to food and nutraceutical products by direct analysis in real time/orbitrap mass spectrometry. Food Control. 2012; 25(1): 13-6.
48. Segura PA, Tremblay P, Picard P, Gagnon C, Sauve S. High-throughput quantitation of seven sulfonamide residues in dairy milk using laser diode thermal desorption-negative mode atmospheric pressure chemical ionization tandem mass spectrometry. Journal of Agricultural and Food Chemistry. 2010; 58(3): 1442-6.
49. Nielen MW, Nijrolder AW, Hooijerink H, Stolker AA. Feasibility of desorption electrospray ionization mass spectrometry for rapid screening of anabolic steroid esters in hair. Analytica Chimica Acta. 2011; 700(1-2): 63-9.
50. Pfaff AM, Steiner RR. Development and validation of AccuTOF-DART™ as a screening method for analysis of bank security device and pepper spray components. Forensic Science International. 2011; 206(1-3): 62-70.
51. Steinfeld JI, Wormhoudt J. Explosives detection: a challenge for physical chemistry. Annual Review of Physical Chemistry. 1998; 49(1): 203-32.
52. Nilles JM, Connell TR, Stokes ST, Dupont Durst H. Explosives detection using direct analysis in real time (DART) mass spectrometry. Propellants, Explosives, Pyrotechnics. 2010; 35(5): 446-51.