Author(s): A. S. Shendge, D. T. Tayade*, P. R. Kale

Email(s): anilsphd@gmail.com , skdtayade@mail.com.

DOI: 10.5958/2231-5675.2017.00034.5   

Address: A. S. Shendge, D. T. Tayade*, P. R. Kale
Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati 444604.
*Corresponding Author

Published In:   Volume - 7,      Issue - 4,     Year - 2017


ABSTRACT:
A novel method has been developed for the synthesis of 2-(3-substitutedamino-2,4-dithiobiuretoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1,3-thiazoles by the reaction of 2-(3-substitutedthioamidoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1,3-thiazoles with substituted isothiocyanate in 60% ethanol-acetone. The method provides rapid and easy access to compounds in good yields by using 60% ethanol-acetone medium.


Cite this article:
A. S. Shendge, D. T. Tayade*, P. R. Kale. Synthesis of 2-(3-Substitutedamino-2,4-Dithiobiuretoformamidino-4-isobutoxyphenyl)-4-Methyl-5-Carboxy-1,3-Thiazoles. Asian J. Pharm. Ana. 2017; 7(4): 214-217. doi: 10.5958/2231-5675.2017.00034.5


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