Author(s): V. S. Tambe*, M. N. Deodhar, Vijayalakshmi Prakya

Email(s): vrushali.tambe@rediffmail.com

DOI: 10.5958/2231-5675.2017.00032.1   

Address: V. S. Tambe*1, M. N. Deodhar2, Vijayalakshmi Prakya3
1J.N.T. University, Hyderabad and PES Modern College of Pharmacy for Ladies, Pune
2J.N.T. University, Hyderabad and S.G.R.S. College of Pharmacy, Pune
3Siddhartha Institute of Pharmacy, J.N.T. University, Hyderabad
*Corresponding Author

Published In:   Volume - 7,      Issue - 4,     Year - 2017


ABSTRACT:
The present study describes new, simple, rapid and novel spectrophotometric methods for simultaneous estimation of Tramadol Hydrochloride and Ketorolac Tromethamine in bulk and capsule formulation. The combination was analysed by simultaneous equation method (Method A), Absorbance correction method (Method B) and First order derivative spectroscopic method (Method C). Method A involved measurement of absorbance at two wavelengths, 271 nm and 246 nm, ?max of Tramadol hydrochloride and Ketorolac tromethamine respectively. For method B, wavelengths 331 nm (for determination of Ketorolac tromethamine) and 271 nm were used. For method C, wavelengths 339.2 nm (Zero crossing of Tramadol hydrochloride) and 229.4 nm (Zero crossing of Ketorolac tromethamine) were used for determination of Ketorolac tromethamine and Tramadol hydrochloride respectively. Beer’s law was obeyed in concentration range of 5-50 µg/ ml and 2-20 µg/ ml for Tramadol hydrochloride and Ketorolac tromethamine respectively by all the methods. Method C was found to be more simple and sensitive. The proposed methods are recommended for routine analysis of pharmaceutical formulations due to their specificity, rapidity, simplicity and accuracy. These methods were validated for linearity, accuracy and precision as per ICH guidelines.


Cite this article:
V. S. Tambe, M. N. Deodhar, Vijayalakshmi Prakya. Validated Simultaneous UV Spectrophotometric Methods for estimation of Tramadol Hydrochloride and ketorolac Tromethamine in bulk and marketed Capsule Formulation. Asian J. Pharm. Ana. 2017; 7(4): 203-208. doi: 10.5958/2231-5675.2017.00032.1


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DOI: 10.5958/2231–5675 

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