Author(s): Saroj Gajare, Amar Zalte, Ravindra B. Saudagar

Email(s): sarojgajare19@gmail.com

DOI: 10.5958/2231-5675.2017.00013.8   

Address: Saroj Gajare1*, Prof. Amar Zalte2, Dr. Ravindra B. Saudagar3
1Department of Quality Assurance, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik (Dt),
2Department of Pharmaceutics , R.G. Sapkal College of Pharmacy, Anjaneri, Nasik (Dt),
3Department of Pharmaceutical Sciences, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik (Dt),
*Corresponding Author

Published In:   Volume - 7,      Issue - 2,     Year - 2017


ABSTRACT:
Simple, precise and economical UV Spectrophotometric methods have been developed for the simultaneous estimation of Linagliptin and Metformin in bulk and pharmaceutical dosage forms. The simultaneous equation (Vierodt’s Method), which is based on measurement of absorption at 227nm and 232nm i.e. ?max of Linagliptin and Metformin respectively. Linearity was observed in the concentration range of 1-11µg/ml for Linagliptin and 3-13 µg/ml. The accuracy of methods was assessed by recovery studies and was found to be withinrange of 98-99% for both Linagliptin and Metformin.The developed methods were validated with respect tolinearity, accuracy (recovery), and precision. The method can be employed for estimation of pharmaceuticalformulations with no interference from any other excipients and diluents. The results were validated statistically as per ICH Q2 R1 guidelines and were found to be satisfactory.


Cite this article:
Saroj Gajare, Amar Zalte, Ravindra B. Saudagar. Simultaneous Spectrophotometric Determination of Linagliptin and Metformin Hydrochloride in Combined Tablet Dosage Form. Asian J. Pharm. Ana. 2017; 7(2): 79-83. doi: 10.5958/2231-5675.2017.00013.8


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DOI: 10.5958/2231–5675 

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