Author(s): Sayed M Derayea, Mahmoud A Omar, Mohamed Aboel-Kasem Abdel-Lateef

Email(s): sayed.derayea@gmail.com

DOI: 10.5958/2231-5675.2016.00029.6   

Address: Sayed M Derayea1*, Mahmoud A Omar 1, Mohamed Aboel-Kasem Abdel-Lateef2
1Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
2Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut 71524, Egypt
*Corresponding Author

Published In:   Volume - 6,      Issue - 4,     Year - 2016


ABSTRACT:
A simple, sensitive and cost effective method was developed and validated for the determination of some ß-adrenergic blocking agents namely; carvedilol, labetalol hydrochloride, nebivolol hydrochloride and sotalol hydrochloride. The method was based on the ability of the cited drugs to induce the formation of silver nanoparticles (Ag-NPs) in the presence of polyvinyl pyrrolidone as a stabilizer. The intense surface plasmon resonance of the formed nanoparticles appeared at 420 nm, was utilized for the quantitative spectrophotometric determination of the beta-blockers. The linear concentration ranges were 0.05 – 1.6, 0.16 – 3.0, 0.2 – 2.5 and 0.10 – 2.0 µg mL-1 for carvedilol, labetalol hydrochloride, nebivolol hydrochloride and sotalol hydrochloride respectively with limits of detection of 30, 53, 62 and 34 ng mL-1, respectively. The commercial dosage forms containing the studied drugs were analyzed by the proposed method and the results were compared statistically with those obtained by the reported methods. The comparison revealed high precision and accuracy of the suggested method. Moreover, the method was extended to the content uniformity testing of commercial tablets dosage forms.


Cite this article:
Sayed M Derayea, Mahmoud A Omar , Mohamed Aboel-Kasem Abdel-Lateef. Nano-level detection of certain beta-blockers based on surface plasmon resonance band of silver nanoparticles; Application to content uniformity test. Asian J. Pharm. Ana. 2016; 6(4): 193-200.. doi: 10.5958/2231-5675.2016.00029.6


Recomonded Articles:

Author(s): Santosh Gada, Anand Kumar Y, Saritha, C. Mallikarjuna Setty

DOI: 10.5958/2231-5675.2018.00036.4         Access: Open Access Read More

Author(s): K. Pramod, Shahid H. Ansari, Javed Ali

DOI:         Access: Open Access Read More

Author(s): Sushil D. Patil, Sayali K. Chaure, Maswood Ahmed Hafizur Rahman, Prajkta U. Varpe, Sanjay Kshirsagar.

DOI: 10.5958/2231-5675.2017.00004.7         Access: Open Access Read More

Author(s): G. Krishnamoorthy, C. Diana Priyadarshini, R. Senthamarai

DOI:         Access: Open Access Read More

Author(s): Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain

DOI: 10.5958/2231-5675.2015.00025.3         Access: Open Access Read More

Author(s): Saroj Kumar Raul, Bukkuru Spandana, Patibandla Sameera, Vegiraju Vikitha

DOI:         Access: Open Access Read More

Author(s): Mansi J. Chaudhari, Suraj R. Chaudhari, Shailesh S. Chalikwar, Atul A. Shirkhedkar

DOI: 10.5958/2231-5675.2018.00008.X         Access: Open Access Read More

Author(s): S. Vidyadhara, RLC Sasidhar, B. Venkateswara Rao, P. Ratna Kumari

DOI:         Access: Open Access Read More

Author(s): Yogita R. Indalkar, Aloorkar N.H.

DOI: 10.5958/2231-5675.2015.00028.9         Access: Open Access Read More

Author(s): Madhavi R., Mohana Krishna A., Shobha Rani G., Mounika D.

DOI: 10.5958/2231-5675.2015.00008.3         Access: Open Access Read More

Author(s): Shobha Rani G, Lohita M, Jaya Preethi P, Madhavi R, Sunisitha B, Mounika D

DOI:         Access: Open Access Read More

Author(s): Saroj Kumar Raul, Gopal Krishna Padhy, Pramudula Ramya Krishna, Boddu Uma Madhu Priya

DOI:         Access: Open Access Read More

Author(s): U. Viplava Prasad, M. Syam Bab, B. Kalyana Ramu

DOI: 10.5958/2231-5675.2017.00012.6         Access: Open Access Read More

Author(s): Kathirvel S., Raju R., Seethadevi B., Suneetha A.,Jyothisree K.

DOI: 10.5958/2231-5675.2015.00014.9         Access: Open Access Read More

Author(s): K. Pramod, Shahid H. Ansari, Javed Ali

DOI:         Access: Open Access Read More

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 

Popular Articles


Recent Articles




Tags