Author(s): Vishakha D. Patel, Hasumati A. Raj, Nirav K. Gheewala

Email(s): vishuk7293@gmail.com , drharaj@yahoo.com

DOI: 10.5958/2231-5675.2016.00004.1   

Address: Vishakha D. Patel, Hasumati A. Raj, Nirav K. Gheewala
Shree Dhanvantary College of Pharmacy, Kim, Surat, Gujarat, India.
*Corresponding Author

Published In:   Volume - 6,      Issue - 1,     Year - 2016


ABSTRACT:
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Amiodarone Hydrochloride and Ranolazine in synthetic mixture using Second order derivative zero-crossing method. Amiodarone HCl showed zero crossing point at 249.20 nm while Ranolazine showed zero crossing point at 263.20 nm. The dA/d? was measured at 263.20 nm for Amiodarone HCl and 249.20 nm for Ranolazine and calibration curves were plotted as 2dA/2d? versus concentration, respectively The linear correlation was obtained (r2>0.9996) in the range of 1-20 µg/ml for Amiodarone HCl at 263.20 nm. The method was found to be linear (r2>0.9996) in the range of 10-200 µg/ml for Ranolazine 249.20 nm. The limit of determination was 0.235µg/ml and 0.271µg/ml for Amiodarone HCl and Ranolazine, respectively. The limit of quantification was 0.712µg/ml and 0.823µg/ml for Amiodarone HCl and Ranolazine, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99% shows Second order derivation zero crossing. The method was successfully applied for simultaneous determination of Amiodarone HCl and Ranolazine in binary mixture.


Cite this article:
Vishakha D. Patel, Hasumati A. Raj, Nirav K. Gheewala. Second Derivative Spectroscopic Method for Simultaneous estimation of Amiodarone Hydrochloride and Ranolazine in synthetic mixture. Asian J. Pharm. Ana. 6(1): January- March, 2016; Page 23-30. doi: 10.5958/2231-5675.2016.00004.1


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Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

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DOI: 10.5958/2231–5675 

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