Author(s): Niraj Vyas, Sangita Panchal

Email(s): nirajvyas.ph@charusat.ac.in

DOI: Not Available

Address: Niraj Vyas* and Sangita Panchal
Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, At & Post- Changa, Ta- Petlad, Dist. - Anand, 388421, Gujarat, India.
.*Corresponding Author

Published In:   Volume - 4,      Issue - 3,     Year - 2014


ABSTRACT:
A simple, sensitive, precise and specific Reverse Phase High Performance Liquid Chromatographic method was developed and validated for the determination of Nebivolol and Indapamide in bulk and tablet dosage form. It was found that the excipient in the tablet dosage form does not interfere in the quantification of active drug by proposed method. The HPLC separation was carried out by reverse phase chromatography by Inertsil ODS C-18 (150 x 4.6 mm) column with a mobile phase composed of Buffer: Acetonitrile (60:40) in isocratic mode at a flow rate of 1ml/min. The detection was monitored at 282 nm. The calibration curve for Nebivolol and Indapamide was linear from 25-225 µg/ml and 7.5-67.5 µg/ml respectively. The inter-day and intra-day precision was found to be within limits. The proposed method has adequate sensitivity, reproducibility and specificity for the determination of Nebivolol and Indapamide.


Cite this article:
Niraj Vyas, Sangita Panchal. Development and Validation of RP-HPLC Method for Simultaneous Estimation of Nebivolol and Indapamide in Pharmaceutical Dosage Form. Asian J. Pharm. Ana. 4(3): July-Sept. 2014; Page 98-102.


Recomonded Articles:

Author(s): Sushil D. Patil, Sunil V. Amurutkar, C.D. Upasani

DOI: 10.5958/2231-5675.2016.00030.2         Access: Open Access Read More

Author(s): Santosh Gada, Anand Kumar Y, Saritha, C. Mallikarjuna Setty

DOI: 10.5958/2231-5675.2018.00036.4         Access: Open Access Read More

Author(s): K. Pramod, Shahid H. Ansari, Javed Ali

DOI:         Access: Open Access Read More

Author(s): Kirthi A, Shanmugam R, Mohana Lakshmi S , Ashok Kumar CK, Padmini K, Shanti Prathyusha M, Shilpa V

DOI:         Access: Open Access Read More

Author(s): Sushil D. Patil, Sayali K. Chaure, Maswood Ahmed Hafizur Rahman, Prajkta U. Varpe, Sanjay Kshirsagar.

DOI: 10.5958/2231-5675.2017.00004.7         Access: Open Access Read More

Author(s): Duggi Adilakshmi, Abdul Saleem Mohammad, Nuha Rasheed, Kathula Umadevi, Chandana Pasupuleti

DOI: 10.5958/2231-5675.2016.00025.9         Access: Open Access Read More

Author(s): Hamid Khan, Javed Ali

DOI: 10.5958/2231-5675.2017.00020.5         Access: Open Access Read More

Author(s): Pinaz A. Kasad, K.S. Muralikrishna

DOI:         Access: Open Access Read More

Author(s): G. Krishnamoorthy, C. Diana Priyadarshini, R. Senthamarai

DOI:         Access: Open Access Read More

Author(s): Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain

DOI: 10.5958/2231-5675.2015.00025.3         Access: Open Access Read More

Author(s): P. Janaki Pathi, N. Appala Raju, G.Parvathalu

DOI:         Access: Open Access Read More

Author(s): Saroj Kumar Raul, Bukkuru Spandana, Patibandla Sameera, Vegiraju Vikitha

DOI:         Access: Open Access Read More

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 

Popular Articles


Recent Articles




Tags