Author(s):
Ratan Bahadur Mahatara, Sajan Maharjan, Roshni Thapa, Uttam Budhathoki
Email(s):
maharjansajan02@gmail.com
DOI:
10.52711/2231-5675.2025.00002 
Address:
Ratan Bahadur Mahatara1, Sajan Maharjan2*, Roshni Thapa1, Uttam Budhathoki1
1Department of Pharmacy, School of Science, Kathmandu University, Dhulikhel, Nepal.
2Department of Pharmacy, CiST College, New Baneshwor, Kathmandu, Nepal.
*Corresponding Author
Published In:
Volume - 15,
Issue - 1,
Year - 2025
ABSTRACT:
Ranolazine is a novel anti-anginal drug used in the treatment of chronic stable angina in adults. The present study was designed with an objective to develop and validate a simple, fast, precise, selective and accurate Reverse phase high performance liquid chromatography (RP-HPLC) method for quantitative estimation of Ranolazine in bulk drugs and in selected dosage forms. The efficient chromatographic separation was achieved on a SunShell C18 column (150mm X 4.6mm, 2.6µm particle size) as stationary phase with a mobile phase consisting of buffer (0.01M Ammonium acetate pH adjusted to 5.0 with diluted acetic acid) and the methanol in the ratio of 40:60 v/v at a flow rate of 1.0ml/min and the detection wavelength was 273nm. The method was statistically validated for linearity, accuracy (recovery), precision, specificity, robustness, and forced degradation study. The method was successfully applied for analysis of a tablet formulation.
Cite this article:
Ratan Bahadur Mahatara, Sajan Maharjan, Roshni Thapa, Uttam Budhathoki. Analytical Method Validation of Ranolazine tablets by RP-HPLC. Asian Journal of Pharmaceutical Analysis. 2025;15(1):7-2. doi: 10.52711/2231-5675.2025.00002
Cite(Electronic):
Ratan Bahadur Mahatara, Sajan Maharjan, Roshni Thapa, Uttam Budhathoki. Analytical Method Validation of Ranolazine tablets by RP-HPLC. Asian Journal of Pharmaceutical Analysis. 2025;15(1):7-2. doi: 10.52711/2231-5675.2025.00002 Available on: https://ajpaonline.com/AbstractView.aspx?PID=2025-15-1-2
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