Author(s): Mahawar Sheetal

Email(s): sheetal.mpharmndds@gmail.com

DOI: Not Available

Address: Mahawar Sheetal*
Department of Pharmacy, Shri Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, India
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2013


ABSTRACT:
The present investigation aimed at development and validation of an analytical method for the estimation of Docetaxel based on Ultra-violet Spectrophotometry. The reported methods of analysis include the chromatographic methods such as HPLC (1-2), RP-HPLC (3-4), LC-MS/MS (18) and HPLC/MS in plasma (5-7). An ion-pair extractive spectrophotometric method has been reported in the literature for the determination of a docetaxel (8). Chromatographic methods are complex, tedious, time consuming and are not suitable for routine analysis. However, Ultraviolet spectrophotometric methods which are simple and fast are ideal for routine analysis. Docetaxel exhibits a sharp peak at 229nm when scanned in the Ultraviolet region. Thus, it was selected as the analytical wave-length. The developed method was found to be simple, sensitive, accurate, precise and specific as evidenced by non-interference from the excipients present in the marketed injection. Linearity was observed in the range of 5µg/ml to 45µg/ml and Accuracy was found between 99.36 to 101.75%. The limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.174µ/ml & 0.194µ/ml respectively.


Cite this article:
Mahawar Sheetal. A Simple Ultraviolet Spectrophotometric Method for the Estimation of Docetaxel in Bulk Drug and Formulation. Asian J. Pharm. Ana. 3(2): April- June 2013; Page 48-52.


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