Author(s): Sucheta Thombare, Shrikrishna Baokar, Rajendra Patil

Email(s): suchetathombare310@gmail.com

DOI: 10.52711/2231-5675.2024.00025   

Address: Sucheta Thombare*, Shrikrishna Baokar, Rajendra Patil
Department of Pharmaceutical Chemistry Delonix Society`s Baramati College of Pharmacy, Baramati.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2024


ABSTRACT:
The goal is to provide a UV approach that is easy to use, affordable, accurate, and requires less time to estimate the amount of lisinopril in pharmaceutical formulations in bulk. Even though HPLC techniques are recognized in pharmacopoeias, non-chromatographic techniques such simple coupling processes or chemical modifications of lisinopril were similarly effective. The approach is predicated on UV spectroscopic methodology. Pharmaceutical formulations containing lisinopril, an ACE inhibitor that is frequently used to treat heart failure and hypertension, require precise and effective analytical techniques for estimating its amount. This work developed and validated a UV spectrophotometric approach for the quantitative analysis of lisinopril in pharmaceutical formulations as well as bulk form. The technique takes advantage of lisinopril’s natural absorbance properties, with maximal absorption being seen at 223nm. A high correlation coefficient (r = 0.9997) was found in linearity studies done throughout a concentration range of 10-50µg/ml, showing excellent linearity and suitable for quantitative analysis. The International Conference on Harmonization’s (ICH) guidelines were followed during the method’s validation. A detailed evaluation was conducted on a number of parameters, including specificity, robustness, ruggedness, accuracy, and precision (including repeatability and intermediate precision). The method’s accuracy and dependability were validated by validation study results, which fulfilled the exacting standards needed for pharmaceutical analysis. The suggested method’s accuracy was further supported by recovery trials, which showed that it could precisely quantify lisinopril even in the presence of formulation excipients and contaminants. The method’s specificity was demonstrated by interference studies, which also guaranteed that co-existing chemicals frequently found in pharmaceutical formulations would cause little influence.


Cite this article:
Sucheta Thombare, Shrikrishna Baokar, Rajendra Patil. Efficiency Assessment and Verification of Lisinopril by Spectrophotometry. Asian Journal of Pharmaceutical Analysis. 2024; 14(3):142-6. doi: 10.52711/2231-5675.2024.00025

Cite(Electronic):
Sucheta Thombare, Shrikrishna Baokar, Rajendra Patil. Efficiency Assessment and Verification of Lisinopril by Spectrophotometry. Asian Journal of Pharmaceutical Analysis. 2024; 14(3):142-6. doi: 10.52711/2231-5675.2024.00025   Available on: https://ajpaonline.com/AbstractView.aspx?PID=2024-14-3-6


REFERENCES:
1.    http://en.wikipedia.org/wiki/Lisinopril
2.    http://www.drugbank.ca/drugs/DB00722
3.    Indian Pharmacopoeia. Ministry of Health and Family Welfare New Delhi. 2007; 2:1306.
4.    British Pharmacopoeia. Stationery Office Books (TSO) London, United Kingdom. 2005; 2: 1199.
5.    United States Pharmacopoiea-USP-24, NF-19, Asian Edition, United States Pharmacopoeial Convention, INC Twin brook Parkway, Rockville, MD, U.S.A. 2000; 979.
6.    European Pharmacopoeia. European Directorate for Quality medicine and health care; Monograph number ISBN: 9789287160577.1120; 2007: 2277.
7.    British National Formulary. British Medical Associations. Royal Pharmaceutical Society of Great Britain. 2005; 98.
8.    Martindale: The complete drug reference, 36th edition, pharmaceutical press, Lambeth High Street, London. 2009: 1307-1311, 1325-1326.
9.    Stanisz B. Estimation of the applicability of differential spectroscopic method for the determination of lisinopril in tablets and for the evaluation of its stability. Acta Pol. Pharm. 2004; 61(5): 327-334.
10.    Rahman N, Anwar N, Kashif M. Application of pi-acceptors to the spectrophotometric determination of lisonopril in commercial dosage forms. Farmaco. 2005; 60(6-7): 605611.
11.    Paraskevas G, Atta-Politou J, Koupparis M. Spectrophotometric determination of lisinopril in tablets using 1-fluoro-2, 4-dinitrobenzene reagent. J. Pharm. Biomed. Anal.  2002; 29(5): 865-872.
12.    Aktas ES, Ersoy L, Sagirli O. A new spectrofluorimetric method for the determination of lisinopril in tablets. Farmaco. 2003; 58(2): 165-168.
13.    El-Gindy A, Ashour A, Abdel-Fattah L, Shabana MM. Spectrophotometric, spectroflourimetric and LC determination of lisinopril, J. Pharm. Biomed. Anal. 2001; 25(5-6): 913-922.
14.    PART 2: Validation of Analytical Procedure: Methodology Q2B, ICH Harmonized Tripartite Guidelines. 1996: 6-12.



Recomonded Articles:

Author(s): Dipti G. Phadtare, Pawar Amol R, R.B. Saudagar

DOI: 10.5958/2231-5675.2016.00019.3         Access: Closed Access Read More

Author(s): Pankaj Bhamare, Rupal Dubey, Neeraj Upmanyu, Pothuvan Umadoss

DOI: 10.5958/2231-5675.2021.00001.6         Access: Open Access Read More

Author(s): Hamid Khan, Javed Ali

DOI: 10.5958/2231-5675.2017.00020.5         Access: Open Access Read More

Author(s): G. Krishnamoorthy, C. Diana Priyadarshini, R. Senthamarai

DOI:         Access: Open Access Read More

Author(s): K. Pramod, Shahid H. Ansari, Javed Ali

DOI:         Access: Open Access Read More

Author(s): Shobha Rani G, Lohita M, Jaya Preethi P, Madhavi R, Sunisitha B, Mounika D

DOI:         Access: Open Access Read More

Author(s): Sushil D. Patil, Sayali K. Chaure, Maswood Ahmed Hafizur Rahman, Prajkta U. Varpe, Sanjay Kshirsagar.

DOI: 10.5958/2231-5675.2017.00004.7         Access: Open Access Read More

Author(s): Yogita R. Indalkar, Aloorkar N.H.

DOI: 10.5958/2231-5675.2015.00028.9         Access: Open Access Read More

Author(s): Pinaz A. Kasad, K.S. Muralikrishna

DOI:         Access: Open Access Read More

Author(s): Saroj Kumar Raul, Gopal Krishna Padhy, Pramudula Ramya Krishna, Boddu Uma Madhu Priya

DOI:         Access: Open Access Read More

Author(s): S. Subramanya Raj Urs, Bindu M., Ramyashree D., Sowmya K. N.

DOI: 10.5958/2231-5675.2020.00034.4         Access: Open Access Read More

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 


Recent Articles




Tags