Author(s):
Priya R. Wani, Vikram Jadhav, Ashish Jain, Vaishali Jadhav
Email(s):
priyawani703@gmail.com , pharmavikram17@gmail.com , drashishjain80@gmail.com , vaishalikudekar@gmail.com
DOI:
10.52711/2231-5675.2024.00022 
Address:
Priya R. Wani1, Vikram Jadhav2, Ashish Jain3, Vaishali Jadhav4*
1,4Department of Quality Assurance, Shri D. D. Vispute College of Pharmacy and Research Center, Devad, Vichumbe, Gut No.104, Adjacent to Mumbai-Pune Express Highway, Tal. Panvel, Dist. Raigad, Maharashtra, India 410 221.
2Mini Drugs Testing Laboratory, Office of the ADC(I), Central Drugs Standard Control Organization, M/s JWR Logistic Pvt ltd 15-45, National Highway 4B, Panvel - JNPT Highway, Village Padeghar, Post - Vahal, Panvel - Maharashtra, India 410206.
3Department of Pharmacognosy and Phytochemistry, Shri D. D. Vispute College of Pharmacy and Research Center, Devad, Vichumbe, Gut No.104, Adjacent to Mumbai - Pune Express Highway, Tal. Panvel, Dist. Raigad, Maharashtra, India 410 221.
*Corresponding Author
Published In:
Volume - 14,
Issue - 3,
Year - 2024
ABSTRACT:
UV spectrophotometry was performed by Lab India Analytical UV 3092 using methanol as medium. The resolution process was performed in the range of 200–400nm to determine the maximum absorption (? max). The ?max of Nirmatrelvir was found to be 210nm. Measure the absorbance of 10, 20, 30, 40, 50, and 60µg/ml drug solution and measure the maximum absorbance at 210 nm with a blank control. Then draw a graph from the concentration on the X-axis and the absorbance on the Y-axis to get a straight line. Validation parameters such as linearity, precision, specificity, LOD and LOQ, accuracy and robustness were evaluated according to ICH guidelines.
Cite this article:
Priya R. Wani, Vikram Jadhav, Ashish Jain, Vaishali Jadhav. UV Spectrophotometric Method Development and Validation for the Determination of Nirmatrelvir Antiviral Drug in Bulk and its In-house Formulation. Asian Journal of Pharmaceutical Analysis. 2024; 14(3):127-0. doi: 10.52711/2231-5675.2024.00022
Cite(Electronic):
Priya R. Wani, Vikram Jadhav, Ashish Jain, Vaishali Jadhav. UV Spectrophotometric Method Development and Validation for the Determination of Nirmatrelvir Antiviral Drug in Bulk and its In-house Formulation. Asian Journal of Pharmaceutical Analysis. 2024; 14(3):127-0. doi: 10.52711/2231-5675.2024.00022 Available on: https://ajpaonline.com/AbstractView.aspx?PID=2024-14-3-3
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