ABSTRACT:
UV spectroscopic method was developed for the estimation of Dolutegravir in bulk and Formulation.The UV spectrum of Dolutegravir in methanol and water mixture showed ? max at 254nm. Beer’s law is valid in the concentration range of 10-50µg/ml. This method was validated for linearity, accuracy, precision, LOD and LOQ. The method has demonstrated excellent linearity over the range of 10-50µg/ml with regression equation y = 0.030x + 0.008 and regression correlation coefficient r2= 0.998. Moreover, the method was found to be highly sensitive with LOD (2.056µg/ml) and LOQ (6.230µg/ml). Depending on results the given method can be successfully applied for assay of Dolutegravir in formulation.
Cite this article:
Vaishnavi Dulange, G.B. Gajeli. Development and Validation of UV Spectroscopy Method for the Estimation of Dolutegravir in Bulk and Pharmaceutical Dosage Form. Asian Journal of Pharmaceutical Analysis. 2021; 11(3):188-0. doi: 10.52711/2231-5675.2021.00032
Cite(Electronic):
Vaishnavi Dulange, G.B. Gajeli. Development and Validation of UV Spectroscopy Method for the Estimation of Dolutegravir in Bulk and Pharmaceutical Dosage Form. Asian Journal of Pharmaceutical Analysis. 2021; 11(3):188-0. doi: 10.52711/2231-5675.2021.00032 Available on: https://ajpaonline.com/AbstractView.aspx?PID=2021-11-3-2
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