Author(s): Vaishnavi Dulange, G.B. Gajeli

Email(s): dulangevaishnavi12@gmail.com

DOI: 10.52711/2231-5675.2021.00032   

Address: Vaishnavi Dulange*, Dr. G.B. Gajeli
D. S. T. S. Mandal’s College of Pharmacy, Solapur - 413004, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2021


ABSTRACT:
UV spectroscopic method was developed for the estimation of Dolutegravir in bulk and Formulation.The UV spectrum of Dolutegravir in methanol and water mixture showed ? max at 254nm. Beer’s law is valid in the concentration range of 10-50µg/ml. This method was validated for linearity, accuracy, precision, LOD and LOQ. The method has demonstrated excellent linearity over the range of 10-50µg/ml with regression equation y = 0.030x + 0.008 and regression correlation coefficient r2= 0.998. Moreover, the method was found to be highly sensitive with LOD (2.056µg/ml) and LOQ (6.230µg/ml). Depending on results the given method can be successfully applied for assay of Dolutegravir in formulation.


Cite this article:
Vaishnavi Dulange, G.B. Gajeli. Development and Validation of UV Spectroscopy Method for the Estimation of Dolutegravir in Bulk and Pharmaceutical Dosage Form. Asian Journal of Pharmaceutical Analysis. 2021; 11(3):188-0. doi: 10.52711/2231-5675.2021.00032

Cite(Electronic):
Vaishnavi Dulange, G.B. Gajeli. Development and Validation of UV Spectroscopy Method for the Estimation of Dolutegravir in Bulk and Pharmaceutical Dosage Form. Asian Journal of Pharmaceutical Analysis. 2021; 11(3):188-0. doi: 10.52711/2231-5675.2021.00032   Available on: https://ajpaonline.com/AbstractView.aspx?PID=2021-11-3-2


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2.    Dolutegravir [Internet]. Drug bank. [cited 2020 Aug 10]. Available From: https://www.drugbank.ca/drugs/DB08930    
3.    Dolutegravir [Internet]. WHO. [cited 2020 Aug 10]. Available From: https://www.who.int/news-room/detail/22-07-2019-who-recommends-dolutegravir-as-preferred-hiv-treatment-option-in-all-populations
4.    Bhavar G, Aher K. et al. Development and validation of uv spectrophotometric method for estimation of. Dolutegravir sodium in tablet dosage. Malaysian Journal of Analytical Sciences. 2015; 19(6): 1156 - 1163.
5.    K. Bhavyasri et al. Method Development, Validation and Forced Degradation Studies of Dolutegravir, An Anti-Retroviral Drug using Uv-Visible Spectroscopy. Int J Pharm Sci and Scient Res. 2019; 5: (6): 69-74.
6.    Shamla Moideen et al. Method Development and Validation of Simultaneous Estimation of Dolutegravir and Lamivudine in Synthetic Mixtures by UV-Visible Spectroscopy. International Journal of Pharmacy and Pharmaceutical Research. 2020; 17 (4): 375-386.

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