Author(s): Vaishnavi Dulange, G.B. Gajeli

Email(s): dulangevaishnavi12@gmail.com

DOI: 10.52711/2231-5675.2021.00032   

Address: Vaishnavi Dulange*, Dr. G.B. Gajeli
D. S. T. S. Mandal’s College of Pharmacy, Solapur - 413004, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2021


ABSTRACT:
UV spectroscopic method was developed for the estimation of Dolutegravir in bulk and Formulation.The UV spectrum of Dolutegravir in methanol and water mixture showed ? max at 254nm. Beer’s law is valid in the concentration range of 10-50µg/ml. This method was validated for linearity, accuracy, precision, LOD and LOQ. The method has demonstrated excellent linearity over the range of 10-50µg/ml with regression equation y = 0.030x + 0.008 and regression correlation coefficient r2= 0.998. Moreover, the method was found to be highly sensitive with LOD (2.056µg/ml) and LOQ (6.230µg/ml). Depending on results the given method can be successfully applied for assay of Dolutegravir in formulation.


Cite this article:
Vaishnavi Dulange, G.B. Gajeli. Development and Validation of UV Spectroscopy Method for the Estimation of Dolutegravir in Bulk and Pharmaceutical Dosage Form. Asian Journal of Pharmaceutical Analysis. 2021; 11(3):188-0. doi: 10.52711/2231-5675.2021.00032

Cite(Electronic):
Vaishnavi Dulange, G.B. Gajeli. Development and Validation of UV Spectroscopy Method for the Estimation of Dolutegravir in Bulk and Pharmaceutical Dosage Form. Asian Journal of Pharmaceutical Analysis. 2021; 11(3):188-0. doi: 10.52711/2231-5675.2021.00032   Available on: https://ajpaonline.com/AbstractView.aspx?PID=2021-11-3-2


REFERENCES:
1.    Dolutegravir image [Internet]. Wikipedia. [cited 2020 Aug 10]. Available From: https://en.wikipedia.org/wiki/Dolutegravir
2.    Dolutegravir [Internet]. Drug bank. [cited 2020 Aug 10]. Available From: https://www.drugbank.ca/drugs/DB08930    
3.    Dolutegravir [Internet]. WHO. [cited 2020 Aug 10]. Available From: https://www.who.int/news-room/detail/22-07-2019-who-recommends-dolutegravir-as-preferred-hiv-treatment-option-in-all-populations
4.    Bhavar G, Aher K. et al. Development and validation of uv spectrophotometric method for estimation of. Dolutegravir sodium in tablet dosage. Malaysian Journal of Analytical Sciences. 2015; 19(6): 1156 - 1163.
5.    K. Bhavyasri et al. Method Development, Validation and Forced Degradation Studies of Dolutegravir, An Anti-Retroviral Drug using Uv-Visible Spectroscopy. Int J Pharm Sci and Scient Res. 2019; 5: (6): 69-74.
6.    Shamla Moideen et al. Method Development and Validation of Simultaneous Estimation of Dolutegravir and Lamivudine in Synthetic Mixtures by UV-Visible Spectroscopy. International Journal of Pharmacy and Pharmaceutical Research. 2020; 17 (4): 375-386.

Recomonded Articles:

Author(s): Sushil D. Patil, Sunil V. Amurutkar, C.D. Upasani

DOI: 10.5958/2231-5675.2016.00030.2         Access: Open Access Read More

Author(s): K. Pramod, Shahid H. Ansari, Javed Ali

DOI:         Access: Open Access Read More

Author(s): Sushil D. Patil, Sayali K. Chaure, Maswood Ahmed Hafizur Rahman, Prajkta U. Varpe, Sanjay Kshirsagar.

DOI: 10.5958/2231-5675.2017.00004.7         Access: Open Access Read More

Author(s): Kirthi A, Shanmugam R, Mohana Lakshmi S , Ashok Kumar CK, Padmini K, Shanti Prathyusha M, Shilpa V

DOI:         Access: Open Access Read More

Author(s): G. Krishnamoorthy, C. Diana Priyadarshini, R. Senthamarai

DOI:         Access: Open Access Read More

Author(s): Santosh Gada, Anand Kumar Y, Saritha, C. Mallikarjuna Setty

DOI: 10.5958/2231-5675.2018.00036.4         Access: Open Access Read More

Author(s): Pinaz A. Kasad, K.S. Muralikrishna

DOI:         Access: Open Access Read More

Author(s): Yogita R. Indalkar, Aloorkar N.H.

DOI: 10.5958/2231-5675.2015.00028.9         Access: Open Access Read More

Author(s): B. Thangabalan, M. Salomi, N. Sunitha, S. Manohar Babu

DOI:         Access: Open Access Read More

Author(s): Jayshree Pawar, Sandeep Sonawane, Santosh Chhajed, Sanjay Kshirsagar

DOI: 10.5958/2231-5675.2016.00024.7         Access: Open Access Read More

Author(s): Saroj Kumar Raul, Gopal Krishna Padhy, Pramudula Ramya Krishna, Boddu Uma Madhu Priya

DOI:         Access: Open Access Read More

Author(s): K. Pramod, Shahid H. Ansari, Javed Ali

DOI:         Access: Open Access Read More

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 

Popular Articles


Recent Articles




Tags