Author(s): Ajay I. Patel, Shweta V. Gosai, Amikumar J. Vyas, Nilesh K. Patel, Ashok B. Patel

Email(s): shwetagosai97@gmail.com

DOI: 10.5958/2231-5675.2020.00035.6   

Address: Dr. Ajay I. Patel, Shweta V. Gosai*, Dr. Amikumar J. Vyas, Dr. Nilesh K. Patel, Dr. Ashok B. Patel
Pharmaceutical Quality Assurance Department, B. K. Mody Government Pharmacy College, Rajkot, Gujarat, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2020


ABSTRACT:
To develop sensitive, accurate, precise and understandable UV spectrophotometric method for estimation of Propranolol hydrochloride and Rosuvastatin calcium in synthetic mixture. First order derivative simultaneous estimation was carried out by using UV visible double beam spectrophotometer. Propranolol hydrochloride and rosuvastatin calcium exhibited absorbance at working wavelength 239.43nm and 249.03nm respectively using distilled water as a solvent. Linearity was found in range of 1-24µg/ml for propranolol hydrochloride and rosuvastatin calcium. Accuracy was obtained between 95.40-103.40% that is 101.50% for Propranolol hydrochloride and 100.16% for Rosuvastatin calcium. Method was validated for its linearity, accuracy, precision, LOD, LOQ and robustness as per ICH guidelines. The aforementioned method was found specified for estimation of synthetic mixture without interference.


Cite this article:
Ajay I. Patel, Shweta V. Gosai, Amikumar J. Vyas, Nilesh K. Patel, Ashok B. Patel. UV Spectrophotometric Estimation of Propranolol Hydrochloride and Rosuvastatin Calcium in Synthetic mixture using First Order Derivative Method. Asian J. Pharm. Ana. 2020; 10(4):189-194. doi: 10.5958/2231-5675.2020.00035.6


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