Author(s): Omkar A. Patil, Indrajeet S. Patil, Ganesh B. Vambhurkar, Dheeraj S. Randive, Mangesh A. Bhutkar, Srinivas K. Mohite

Email(s): omkarpatil3332@gmail.com

DOI: 10.5958/2231-5675.2018.00023.6   

Address: Omkar A. Patil*, Indrajeet S. Patil, Ganesh B. Vambhurkar, Dheeraj S. Randive, Dr. Mangesh A. Bhutkar, Dr. Srinivas K. Mohite
Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra India- 415404
*Corresponding Author

Published In:   Volume - 8,      Issue - 3,     Year - 2018


ABSTRACT:
Pioglitazone is an antidiabetic agent from thiazolidinedione class which is used in the treatment of Type 2 diabetes mellitus. It activates PPAR-? found in adipose tissue, pancreatic ß-cells, vascular endothelium and macro-phages. Degradation is a main problem in numerous unstable products. As per the ICH guidelines factors which causes degradation of a drug product comprise of temperature, time, photo degradation, pH variation (high and low), acid/base stress testing and/ or with humidity. In our research work UV-V spectroscopy method was designed to examine and calculate the quantity of drug in the presence of degradation products. WHO, the official assay limit of the content should not less than 98% and not more than 102% of labelled amount of Pioglitazone. From the results of our study it can concluded that Pioglitazone degrades most when exposed to the basic medium and heat but do not undergo degradation in acidic medium, whereas slight degradation occurs in the UV.


Cite this article:
Omkar A. Patil, Indrajeet S. Patil, Ganesh B. Vambhurkar, Dheeraj S. Randive, Mangesh A. Bhutkar, Srinivas K. Mohite. UV Spectroscopic Degradation Study of Pioglitazone Hydrochloride. Asian J. Pharm. Ana. 2018; 8(3):125-128. doi: 10.5958/2231-5675.2018.00023.6


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DOI: 10.5958/2231–5675 

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