Author(s): A. Suneetha, V. Mounika, Shaik Mahammad Sajid

Email(s): drasuneetha@gmail.com

DOI: 10.5958/2231-5675.2020.00014.9   

Address: A. Suneetha*, V. Mounika, Shaik Mahammad Sajid
Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur, A.P India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 2,     Year - 2020


ABSTRACT:
A new simple, sensitive, accurate, precise and reproducible RP-HPLC method has been developed for the simultaneous estimation of sitagliptin and ertugliflozin in bulk and pharmaceutical dosage form using Inertsil ODS (4.6×150mm, 5µ) column in isocratic mode. The mobile phase consisted 0.1% TFA: Methanol: Acetonitrile (30: 60: 10). The detection was carried out at 250nm. The method was linear over the concentration range for sitagliptin 40-200µg/ml and for ertugliflozin 6-30µg/ml. The recoveries of sitagliptin and ertugliflozin were found to be 100.26 and 100.18% respectively. The validation of method was carried out utilizing ICH guidelines. The described HPLC method was successfully employed for the analysis of pharmaceutical formulation containing combined dosage form.


Cite this article:
A. Suneetha, V. Mounika, Shaik Mahammad Sajid. Development and Validation of Stability indicating RP-HPLC Method for the simultaneous Estimation of Sitagliptin and Ertugliflozin in bulk and Tablet Dosage Forms. Asian J. Pharm. Ana. 2020; 10(2): 81-85. doi: 10.5958/2231-5675.2020.00014.9

Cite(Electronic):
A. Suneetha, V. Mounika, Shaik Mahammad Sajid. Development and Validation of Stability indicating RP-HPLC Method for the simultaneous Estimation of Sitagliptin and Ertugliflozin in bulk and Tablet Dosage Forms. Asian J. Pharm. Ana. 2020; 10(2): 81-85. doi: 10.5958/2231-5675.2020.00014.9   Available on: https://ajpaonline.com/AbstractView.aspx?PID=2020-10-2-4


Recomonded Articles:

Author(s): Sushil D. Patil, Sunil V. Amurutkar, C.D. Upasani

DOI: 10.5958/2231-5675.2016.00030.2         Access: Open Access Read More

Author(s): Dipti G. Phadtare, Pawar Amol R, R.B. Saudagar

DOI: 10.5958/2231-5675.2016.00019.3         Access: Closed Access Read More

Author(s): Pankaj Bhamare, Rupal Dubey, Neeraj Upmanyu, Pothuvan Umadoss

DOI: 10.5958/2231-5675.2021.00001.6         Access: Open Access Read More

Author(s): Hamid Khan, Javed Ali

DOI: 10.5958/2231-5675.2017.00020.5         Access: Open Access Read More

Author(s): K. Pramod, Shahid H. Ansari, Javed Ali

DOI:         Access: Open Access Read More

Author(s): G. Krishnamoorthy, C. Diana Priyadarshini, R. Senthamarai

DOI:         Access: Open Access Read More

Author(s): Shobha Rani G, Lohita M, Jaya Preethi P, Madhavi R, Sunisitha B, Mounika D

DOI:         Access: Open Access Read More

Author(s): S. Subramanya Raj Urs, Bindu M., Ramyashree D., Sowmya K. N.

DOI: 10.5958/2231-5675.2020.00034.4         Access: Open Access Read More

Author(s): Saroj Kumar Raul, Gopal Krishna Padhy, Pramudula Ramya Krishna, Boddu Uma Madhu Priya

DOI:         Access: Open Access Read More

Author(s): Sri Lakshmi D, Jane T Jacob, Srinivasa Sastry D, Satyanarayana D

DOI: 10.5958/2231-5675.2017.00005.9         Access: Open Access Read More

Author(s): Santosh Gada, Anand Kumar Y, Saritha, C. Mallikarjuna Setty

DOI: 10.5958/2231-5675.2018.00036.4         Access: Open Access Read More

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 


Recent Articles




Tags