Author(s): Sobhy M. El-Adl, Mohamed El. Hossinny El. Sadek, Marwa Hamdy Hassan

Email(s): elmohands_eg@yahoo.com

DOI: Not Available

Address: Sobhy M. El-Adl, Mohamed El. Hossinny El. Sadek , Marwa Hamdy Hassan
Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt.
*Corresponding Author

Published In:   Volume - 4,      Issue - 4,     Year - 2014


ABSTRACT:
Two spectrophotometric methods are described for determination of Clarithromycin , Clindamycin and Cefixime in bulk and pharmaceutical dosage forms using insitu generated bromine as oxidizing agent and either methylene blue or methyl orange as chromogenic agents. Drugs are treated with known excess of bromine and residual unreacted bromine is determined by treating with fixed amount of either methylene blue or methyl orange then measuring absorbance at (666nm for clindamycin and cefixime or 678 nm for clarithromycin) and 510 nm respectively. The amount of bromine reacted corresponds to the amount of each drug. The effect’s of acidity, bromate-bromide volume and time, on the absorption were studied. Calibration curves were linear over ranges of 3.2–16 µg.ml-1 for Clarithromycin,1.6- 4.8 µg.ml-1 for Clindamycin, 0.8-7.2 µg.ml-1 for Cefixime in case of methylene blue and of 6.4–19.2 µg.ml-1 for Clarithromycin, 0.8-4.0µg.ml-1 for Clindamycin, 0.4-2 µg.ml-1 for Cefixime in case of methyl orange. The methods were satisfactory applied for the determination of drugs in both bulk and pharmaceutical dosage forms and results were compared statistically with reference methods.


Cite this article:
Sobhy M. El-Adl, Mohamed El. Hossinny El. Sadek , Marwa Hamdy Hassan. Bromometric Estimation of Cefixime, Clarithromycin and Clindamycin in Bulk and Dosage Forms. Asian J. Pharm. Ana. 4(4): Oct. - Dec. 2014; Page 137-146.


Recomonded Articles:

Author(s): K. Pramod, Shahid H. Ansari, Javed Ali

DOI:         Access: Open Access Read More

Author(s): Santosh Gada, Anand Kumar Y, Saritha, C. Mallikarjuna Setty

DOI: 10.5958/2231-5675.2018.00036.4         Access: Open Access Read More

Author(s): Kirthi A, Shanmugam R, Mohana Lakshmi S , Ashok Kumar CK, Padmini K, Shanti Prathyusha M, Shilpa V

DOI:         Access: Open Access Read More

Author(s): Sushil D. Patil, Sayali K. Chaure, Maswood Ahmed Hafizur Rahman, Prajkta U. Varpe, Sanjay Kshirsagar.

DOI: 10.5958/2231-5675.2017.00004.7         Access: Open Access Read More

Author(s): Hamid Khan, Javed Ali

DOI: 10.5958/2231-5675.2017.00020.5         Access: Open Access Read More

Author(s): G. Krishnamoorthy, C. Diana Priyadarshini, R. Senthamarai

DOI:         Access: Open Access Read More

Author(s): P. Janaki Pathi, N. Appala Raju, G.Parvathalu

DOI:         Access: Open Access Read More

Author(s): Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain

DOI: 10.5958/2231-5675.2015.00025.3         Access: Open Access Read More

Author(s): Khushboo Patel*, Dhara Patel, Jaya Dwivedi, Priyanka Newal, Dhananjay Meshram

DOI: 10.5958/2231-5675.2017.00039.4         Access: Open Access Read More

Author(s): B. Thangabalan, M. Salomi, N. Sunitha, S. Manohar Babu

DOI:         Access: Open Access Read More

Author(s): Mansi J. Chaudhari, Suraj R. Chaudhari, Shailesh S. Chalikwar, Atul A. Shirkhedkar

DOI: 10.5958/2231-5675.2018.00008.X         Access: Open Access Read More

Author(s): Saroj Kumar Raul, Bukkuru Spandana, Patibandla Sameera, Vegiraju Vikitha

DOI:         Access: Open Access Read More

Author(s): S. Vidyadhara, RLC Sasidhar, B. Venkateswara Rao, P. Ratna Kumari

DOI:         Access: Open Access Read More

Author(s): Yogita R. Indalkar, Aloorkar N.H.

DOI: 10.5958/2231-5675.2015.00028.9         Access: Open Access Read More

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 

Popular Articles


Recent Articles




Tags