Author(s): Vinod Matole, Avinash Birajdar, Suyash Ingle, Sagar Adlinge, Gajanand Nangare, Saili Madur, Smeeta Patil, Anita Shegaonkar

Email(s): matole7414@gmail.com

DOI: 10.5958/2231-5675.2020.00026.5   

Address: Vinod Matole*, Avinash Birajdar, Suyash Ingle, Sagar Adlinge, Gajanand Nangare, Saili Madur, Smeeta Patil, Anita Shegaonkar
D.S.T.S Mandal’s College of Pharmacy, Solapur-413004, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 3,     Year - 2020


ABSTRACT:
Objective: A new, simple, sensitive, precise and reproducible UV spectroscopic method was developed for the estimation of Acotiamide in bulk and Tablet Formulation. Methods: The UV spectrum of Acotiamide in water showed ? max at 249 nm. Beer’s law is valid in the concentration range of 3-18µg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 3-18µg/ml with regression equation y = 0.0523x - 0.0429 and regression correlation coefficient r2= 0.9996. Moreover, the method was found to be highly sensitive with LOD (0.38µg/ml) and LOQ (1.17µg/ml). Conclusion: Depending on results the given method can be successfully applied for assay of Acotiamide in Tablet formulation.


Cite this article:
Vinod Matole, Avinash Birajdar, Suyash Ingle, Sagar Adlinge, Gajanand Nangare, Saili Madur, Smeeta Patil, Anita Shegaonkar. UV Spectrophotometric Method Development and Validation of Acotiamide in Bulk and Solid Doage Form. Asian J. Pharm. Ana. 2020; 10(3): 147-149. doi: 10.5958/2231-5675.2020.00026.5


REFERENCES:
1. Kusunoki H, et al. Therapeutic efficacy of Acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying: randomized controlled study evaluation by real-time ultrasonography. Wiley Online Library, 2012; 24(6): 540–551. 
2. Matsueda K et al. Clinical trial: dose dependent therapeutic efficacy of Acotiamide(Z-338) in patients with functional dyspepsia – 100 mg t.i.d. is an optimal dosage. Wiley Online Library, 2010; 22(6): 618–e173.
3. Vani R, Sunitha M. Analytical method development and validation for the determination of Acotiamide hydrochloride using reverse phase HPLC method in bulk and tablet dosage form. World journal of pharmacy and pharmaceutical sciences. 2010; 6(10):768-775. 
4. Jing LI, Huang R, Zhi W, Haijun QU, Meijuan S, Zhao Z. Development and Validation of a Sensitive and Specific LC–MS-MS Method for the Determination of Acotiamide in Rat Plasma. Journal of Chromatographic Science. 2016; 54(6):1004–1009.
5. Patel PN, Kalariya PD, Swamy CV, Gananadhamu S, Srinivas R. Quantitation of Acotiamide in rat plasma by UHPLC-Q-TOF-MS: method development, validation and application to pharmacokinetics. Biomed Chromatography. 2016; 30(3): 363-368. 
6. Thummar M, Patel PN, Samanthula G, Ragampeta S. Stability-indicating assay method for Acotiamide: Separation, identification and characterization of its hydroxylated and hydrolytic degradation products along with a process-related impurity by ultra-high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Wiley Online Library, 2017; 31(21): 1813–1824.
7.   ICH Q2 (R1) validation of analytical procedures: text and methodology, International Conference on Harmonization, Nov, 1996. 

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