Vinod Matole, Avinash Birajdar, Suyash Ingle, Sagar Adlinge, Gajanand Nangare, Saili Madur, Smeeta Patil, Anita Shegaonkar
Vinod Matole*, Avinash Birajdar, Suyash Ingle, Sagar Adlinge, Gajanand Nangare, Saili Madur, Smeeta Patil, Anita Shegaonkar
D.S.T.S Mandal’s College of Pharmacy, Solapur-413004, Maharashtra, India.
Volume - 10,
Issue - 3,
Year - 2020
Objective: A new, simple, sensitive, precise and reproducible UV spectroscopic method was developed for the estimation of Acotiamide in bulk and Tablet Formulation. Methods: The UV spectrum of Acotiamide in water showed ? max at 249 nm. Beer’s law is valid in the concentration range of 3-18µg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 3-18µg/ml with regression equation y = 0.0523x - 0.0429 and regression correlation coefficient r2= 0.9996. Moreover, the method was found to be highly sensitive with LOD (0.38µg/ml) and LOQ (1.17µg/ml). Conclusion: Depending on results the given method can be successfully applied for assay of Acotiamide in Tablet formulation.
Cite this article:
Vinod Matole, Avinash Birajdar, Suyash Ingle, Sagar Adlinge, Gajanand Nangare, Saili Madur, Smeeta Patil, Anita Shegaonkar. UV Spectrophotometric Method Development and Validation of Acotiamide in Bulk and Solid Doage Form. Asian J. Pharm. Ana. 2020; 10(3): 147-149. doi: 10.5958/2231-5675.2020.00026.5
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