Author(s): N. Vanaja, Ch. Preethi, S.Y. Manjunath, Krishanu Pal

Email(s): Email ID Not Available

DOI: 10.5958/2231-5675.2015.00027.7   

Address: N. Vanaja*, Ch. Preethi, Dr. S.Y. Manjunath, Krishanu Pal
Department of Pharmaceutical Analysis and Quality Assurance, Srikrupa Institute of Pharmaceutical Sciences, Velkatta, Siddipet,Telangana-502277.
*Corresponding Author

Published In:   Volume - 5,      Issue - 4,     Year - 2015


ABSTRACT:
The present work was aimed at method development and validation for simultaneous estimation of Telmisartan and Chlorthalidone by RP-HPLC in pharmaceutical dosage form. The method was developed by using CAPCELL C18 (250mm×4.6mm id., 5µm). column with a mobile phase consisting Potassium di hydrogen ortho phosphate buffer : Acetonitrile : Methanol (35:45:20 pH 3.5 adjusted with OPA) at flow rate of 0.8mL/min. Retention times were found to be 3.640min. and 4.937min. for Chlorthalidone and Telmisartan respectively. Linearity ranges were found to be 20-100µg/mL and 6.25-31.25 µg/mL for Telmisartan and Chlorthalidone respectively. LOD and LOQ ranges were found to be 0.3074 and 0.9316µg/mL and 0.0579 and 0.1756µg/mL for Telmisartan and Chlorthalidone respectively. Theoretical plates and tailing factors were found to be 5648.33 and 1.58 and 6141.47 and 1.71 for Chlorthalidone and Telmisartan respectively. This method was validated using ICH guidelines.


Cite this article:
N. Vanaja, Ch. Preethi, S.Y. Manjunath, Krishanu Pal. Method Development and Validation for Simultaneous Estimation of Telmisartan and Chlorthalidone by RP-HPLC in Pharmaceutical Dosage Form. Asian J. Pharm. Ana. 5(4): October- December, 2015; Page 171-177. doi: 10.5958/2231-5675.2015.00027.7


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DOI: 10.5958/2231–5675 

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