Author(s): Ashwini Parmar, Sandeep Sonawane, Santosh Chhajed, Sanjay Kshirsagar

Email(s): sandeeps.iop@gmail.com

DOI: 10.5958/2231-5675.2017.00030.8   

Address: Ashwini Parmar, Sandeep Sonawane*, Santosh Chhajed, Sanjay Kshirsagar
MET’s Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik – 422 003, India
*Corresponding Author

Published In:   Volume - 7,      Issue - 3,     Year - 2017


ABSTRACT:
To treat the second stage high blood pressure, physicians prefers the combination drug therapy consisting of two or more anti-hypertensive agents. Among these, telmisartan with amlodipine besylate, telmisartan with hydrochlorthiazide as well as triple drug therapy consisting of amlodipine besylate, telmisartan and hydrochlorthiazide are commonly prescribed. In the present paper, a simple, accurate and precise RP-HPLC method was developed for the estimation of amlodipine besylate, telmisartan and hydrochlorthiazide in bulk and combined dosage form. All these three drugs were successfully separated and resolved from each other on C18 kinetex column (250 × 4.6 mm, 5 µ), using acetonitrile: 20mM phosphate buffer (pH 3.0) (60:40 %, v/v) as a mobile phase at a flow rate of 1 mL/min. The detection was performed at 258 nm. The developed method was further validated as per ICH Q2 (R1) guidelines.


Cite this article:
Ashwini Parmar, Sandeep Sonawane, Santosh Chhajed, Sanjay Kshirsagar. Development and Validation of RP-HPLC Method for simultaneous estimation of Telmisartan, Amlodipine Besylate and Hydrochlorthiazide in their tablet dosage form. Asian J. Pharm. Ana. 2017; 7(3): 189-195. doi: 10.5958/2231-5675.2017.00030.8


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DOI: 10.5958/2231–5675 

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