Author(s): U. Viplava Prasad, M. Syam Bab, B. Kalyana Ramu

Email(s): kalyanaramu23566@gmail.com , msyambab@gmail.com

DOI: 10.5958/2231-5675.2017.00012.6   

Address: U. Viplava Prasad1, M. Syam Bab1*, B. Kalyana Ramu2*
1Department of Organic Chemistry and Analysis of Foods Drugs and Water Laboratories, School of Chemistry, Andhra University, Visakhapatnam-530003 Andhra Pradesh (India)
2Department of Chemistry, Maharajah’s College (Aided and Autonomous), Vizianagaram-535002 (AP) India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 2,     Year - 2017


ABSTRACT:
Purpose: The aim of the investigation was to see the simple and sensitive visible spectrophotometric method for the determination of the sapropterin dihydrochloride either in bulk or tablet dosage forms. Method: A simple, sensitive indirect visible spectrophotometric method has been developed for the estimation of sapropterin dihydrochloride in bulk and dosage forms. The method is based on the oxidation of drug with excess N-Bromo succinimide and determining the unreacted NBS with an oxidisable dye Celestein blue by spectrophotometrically at 522nm Results: Beer’s law obeyed in the concentration range of 4-12 µg/ml. No interference was observed from the usually existing additives in pharmaceutical formulations and the applicability of the method was examined by analyzing kuvan tablets containing SAP. Conclusion: The reported methods for its assay involve sophisticated equipment, which are very costly and pose problems of maintenance. To overcome these problems, the use of visible spectrophotometric technique is justifiable. The statistical data indicates the accuracy, reproducibility and the precision of the proposed method.


Cite this article:
U. Viplava Prasad, M. Syam Bab, B. Kalyana Ramu. Determination of Sapropterin Dihydrochloride in Solid Dosage form by Visible Spectrophotometry. Asian J. Pharm. Ana. 2017; 7(2): 75-78. doi: 10.5958/2231-5675.2017.00012.6


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