Author(s): Roshan Telrandhe

Email(s): Email ID Not Available

DOI: 10.5958/2231-5675.2018.00005.4   

Address: Roshan Telrandhe
Kamla Nehru College of Pharmacy, Butibori, Nagpur 441108, Maharashtra, India *Corresponding Author

Published In:   Volume - 8,      Issue - 1,     Year - 2018


ABSTRACT:
The aimed of research the method development and validation by UV spectrophotometry and RP HPLC method of the Rosuvastatin calcium and Clopidogrel bisulphate. The method is a simple, accurate, specific, precise, reproducible and sensitive. The ? max of ROSU and CLOP was found to be 240nm. The coefficient correlation 0.999, the Beer’s Law limit 50-150 µg/ml, from the four trial of different concentration of mobile phase was selected Methanol:Water 80:20 v/v, pH 3.0 at 240nm, flow rate 1ml/min, sample inlet 20 µL, C 18 Prontosil, %RSD of ROSU 1.017 and CLOP 0.173, theoretical plates ROSU 7797.53 and ROSU 8257.53, Retention time of ROSU 3.483min and CLOP 4.983min, Tailing factor ROSU 1.1787 and CLOP 1.074, limits 2 NMT, Accuracy ROSU 0.37 % RSD, Recovery 99.59% and CLOP 0.18 %RSD, recovery 100.41% was show good efficacy and results. The methods indicate future scope in analysis quality control of the estimation of ROSU and CLOP for routine drug quality analysis investigation.


Cite this article:
Roshan Telrandhe. Development and Validation of UV Spectrophotometry and RP-HPLC Method for simultaneous determination of Rosuvastin and Clopidogrel in Tablet Dosage Form. Asian J. Pharm. Ana. 2018; 8(1): 25-32. doi: 10.5958/2231-5675.2018.00005.4


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DOI: 10.5958/2231–5675 

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