Author(s):
Sourav Duari, Santanu Samanta, R. N. Pal
Email(s):
souravduari2017@gmail.com
DOI:
10.52711/2231-5675.2025.00041 
Address:
Sourav Duari, Santanu Samanta, R. N. Pal
Department of Pharmaceutics, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Maulana Abul Kalam Azad University of Technology, Uluberia, West Bengal, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 4,
Year - 2025
ABSTRACT:
The study was aimed to create and verify a new, straight-forward, accurate, and specific UV-Spectrophotometric analysis method of dasatinib, by comparing in-between three different types of body fluids, having three different pH, like a) gastric fluid, b) physiological fluid c) intestinal fluid, and to determine the best suitable site for administration also. UV spectrophotometric analysis was carried out by utilizing a Shimadzu UV-visible spectrophotometer. The spectrum of the reference solution was run in the 200–400nm range. nm range in order to figure out the absorption maximum (?max) of dasatinib, which was discovered at 323nm. The standard solution’s absorbance of 2,4,6,8 and 10µg/mL was determined the solution of 323nm against the blank. And then the three plots were compared among themselves. Gastric fluid, having a pH value of 1.2, was found to be the best option for determining by the UV spectrophotometry method. The drug dasatinib was best soluble in pH 1.2 buffer as compared with pH 7.4 and 6.8 buffers. In the suggested UV visible spectrophotometry, ICH criteria were followed, and the findings and statistical parameters showed that the development technique was sensitive, exact, and easy to use for dasatinib estimation in bulk form.
Cite this article:
Sourav Duari, Santanu Samanta, R. N. Pal; UV-Spectrophotometric Method Development and Determination of Suitable Medium for Dasatinib by Comparing In-Between Three Body Fluids; Asian Journal of Pharmaceutical Analysis. 2025; 15(4):263-6. doi: 10.52711/2231-5675.2025.00041
Cite(Electronic):
Sourav Duari, Santanu Samanta, R. N. Pal; UV-Spectrophotometric Method Development and Determination of Suitable Medium for Dasatinib by Comparing In-Between Three Body Fluids; Asian Journal of Pharmaceutical Analysis. 2025; 15(4):263-6. doi: 10.52711/2231-5675.2025.00041 Available on: https://ajpaonline.com/AbstractView.aspx?PID=2025-15-4-3
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