Author(s): Tejas G. Jain, Amitkumar R. Dhankani, S. P. Pawar, Mrs. Mansi A. Dhankani

Email(s): jaintejas425410@gmail.com , dhankaniamit@gmail.com , laxmipremchandani3@gmail.com , sppawar75@gmail.com

DOI: 10.52711/2231-5675.2024.00018   

Address: Tejas G. Jain*, Amitkumar R. Dhankani, S. P. Pawar, Mrs. Mansi A. Dhankani
P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Maharashtra.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2024


ABSTRACT:
This paper provides an extensive overview of chromatography techniques utilized in the analysis of Alcaftadine, a pharmaceutical compound used in ophthalmic formulations. Various chromatographic methods including UV Spectrophotometric, HPLC, RP-HPLC, HPTLC, and UPLC have been developed and validated for the accurate quantification of Alcaftadine in bulk and dosage forms. The methods described offer specific advantages such as ease of use, precision, and sensitivity, ensuring reliable results in pharmaceutical analysis. Key parameters of method validation, including accuracy, precision, linearity, limit of detection, limit of quantitation, specificity, range, and robustness, are comprehensively discussed, highlighting the stringent criteria required for analytical method validation in accordance with regulatory guidelines. The importance of stability-indicating methods for assessing the stability of Alcaftadine formulations is emphasized, underscoring the need for robust analytical techniques to ensure product quality and efficacy. The review underscores the crucial role of chromatography in pharmaceutical research, providing valuable insights for researchers and practitioners involved in drug development and quality control.


Cite this article:
Tejas G. Jain, Amitkumar R. Dhankani, S. P. Pawar, Mrs. Mansi A. Dhankani. A State-of-the-Art Review on Chromatographic Analysis of Alcaftadine. Asian Journal of Pharmaceutical Analysis. 2024; 14(2):104-8. doi: 10.52711/2231-5675.2024.00018

Cite(Electronic):
Tejas G. Jain, Amitkumar R. Dhankani, S. P. Pawar, Mrs. Mansi A. Dhankani. A State-of-the-Art Review on Chromatographic Analysis of Alcaftadine. Asian Journal of Pharmaceutical Analysis. 2024; 14(2):104-8. doi: 10.52711/2231-5675.2024.00018   Available on: https://ajpaonline.com/AbstractView.aspx?PID=2024-14-2-9


REFERENCES:
1.    Lodha, L.; Sharma, Neha; Viswas, Amit; Khinchi, M. P. A Review on Chromatography Techniques. AJPRD. 2017; 5(2): 1–8.
2.    Mishra, P. R.; Inamdar, P.; Jamdar, P.; Patel, N.; Rohit, M.; Satone, D.; Meshram, D. B. Development and Validation of Uv-Spectroscopic Methods For The Estimation Of Alcaftadine In Bulk And Its Ophthalmic Dosage Form. 2015; 4 (1).
3.    Rina, R.; Baile, M.; Jain, A. A Review: Analytical Method Development and Validation. Systematic Review Pharmacy. 2021; 12 (8): 450–454.
4.    Mishra, P. R.; Inamdar, P.; Jamdar, P.; Patel, N.; Rohit, M.; Satone, D.; Meshram, D. B. Development and Validation of UV- Spectrophotometry and The First Order Derivative Using The Area Under Curve Method For The Estimation Of Alcaftadine In Bulk And Its Ophthalmic Dosage Form. 2015; 4 (1).
5.    Pr, M.; D, S. Development and Validation of HPLC Method for the Determination of Alcaftadine in Bulk Drug and Its Ophthalmic Solution. J Chromatogr Sep Tech. 2016; 7(1). https://doi.org/10.4172/2157-7064.1000312.
6.    Pundlik, K. M.; V. Shelke, Prof. A.; Jadhav, A. G. Development and Validation of RP-HPLC Method for Estimation of Alcaftadine in Bulk Drug and Dosage Form. IJPSRR. 2022: 134–139. https://doi.org/10.47583/ijpsrr.2022.v76i01.024.
7.    Mali, B. J.; Wagh, R. D. Development and Validation of Hptlc Method for Estimation of Alcaftadine in Bulk and Its Formulation. Indo American Journal of Pharmaceutical Sciences. 2021; 8(1): 2267–2273.
8.    Abdel Razeq, S. A.; Abdel Aziz, S. E.; Ahmed, N. S. Stability-Indicating UPLC, TLC-Densitometric and UV-Spectrophotometric Methods for Alcaftadine Determination. Journal of Chromatography B. 2021; 1177: 122804. https://doi.org/10.1016/j.jchromb.2021.122804.
9.    Patel, I.; Mehta, D. N.; Dalwadi, D. P.; Dharu, N. Stability Indicating RP-HPLC Method Development and Validation for the Simultaneous Estimation of Alcaftadine and Ketorolac Tromethamine in Pharmaceutical Dosage Form. International Journal of All Research Education and Scientific Methods. 2021; 9 (5).
10.    Chavan, B. B.; Vijaya Jyothi, P.; Kalariya, P. D.; Srinivas, R.; Talluri, M. V. N. K. Alcaftadine: Selective Separation and Characterization of Degradation Products by LC–QTOF-MS/MS. Chromatographia. 2018; 81(4): 631–638. https://doi.org/10.1007/s10337-018-3489-1.

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