Author(s): Rucha A Patel, Meghna P. Patel, Hasumati A. Raj, Nehal Shah

Email(s): ruchajigar6114@gmail.com

DOI: 10.5958/2231-5675.2015.00019.8   

Address: Rucha A Patel1*, Meghna P. Patel1, Hasumati A. Raj 1, Nehal Shah2
1Department of Quality Assurance, Shree Dhanvantry Pharmacy College, Kim, Surat, Gujarat, India
2Dharmaj Degree of Pharmacy, Dharmaj, Anand, Gujarat, India
*Corresponding Author

Published In:   Volume - 5,      Issue - 3,     Year - 2015


ABSTRACT:
The proposed study describes an isocratic reversed phase HPLC method for investigation of degradation products of Olmesartan medoxomil API under different stress conditions (acid hydrolysis degradation). Separation of Olmesartan medoxomil and its degradation products was achieved on symmetry C18 (150 mm × 4.6 mm, 5 µ) column using a Acetonitrile: 0.02 M Na2HPO4(45:55 v/v) mobile phase and pH 7 adjusted with ortho phosphoric acid. Isocratic elution mode at a flow rate of 1.0 ml/min at Room temperature with a load of 20µl Injection volume. The detection was carried out at 240 nm followed by Base hydrolysis Structures of the degradation products were studied using a Triple Quadrapole Mass Spectrometer. A separate gradient LCMS method was developed for this purpose Depending on the degradation type, possible chemical reactions were predicted and supported by fragmentation data obtained from LC-MS/NMR. One major products were obtained in solid form using Rotavap and were then analyzed by NMR, IR and TLC to confirm their structural details.


Cite this article:
Rucha A Patel, Meghna P. Patel, Hasumati A. Raj , Nehal Shah. Forced Degradation Studies of Olmesartan Medoxomil and Characterization of Its Major Degradation Products by LC-MS/MS, NMR, IR and TLC. Asian J. Pharm. Ana. 5(3): July- Sept. 2015; Page 119-125. doi: 10.5958/2231-5675.2015.00019.8


Recomonded Articles:

Author(s): Sushil D. Patil, Sunil V. Amurutkar, C.D. Upasani

DOI: 10.5958/2231-5675.2016.00030.2         Access: Open Access Read More

Author(s): Ulhas Balkrishna Hadkar, Asavari Sameer Hadkar

DOI: 10.5958/2231-5675.2018.00004.2         Access: Open Access Read More

Author(s): Mayur N. Ghotkar, Shubham S. Kharade, Rushikesh S. Chavan, Ranjit S. Jadhav, Nisha M. Jagtap, Ganesh B. Vambhurkar

DOI: 10.5958/2231-5675.2018.00033.9         Access: Open Access Read More

Author(s): Kirthi A, Shanmugam R, Mohana Lakshmi S , Ashok Kumar CK, Padmini K, Shanti Prathyusha M, Shilpa V

DOI:         Access: Open Access Read More

Author(s): Hamid Khan, Javed Ali

DOI: 10.5958/2231-5675.2017.00020.5         Access: Open Access Read More

Author(s): Duggi Adilakshmi, Abdul Saleem Mohammad, Nuha Rasheed, Kathula Umadevi, Chandana Pasupuleti

DOI: 10.5958/2231-5675.2016.00025.9         Access: Open Access Read More

Author(s): Pinaz A. Kasad, K.S. Muralikrishna

DOI:         Access: Open Access Read More

Author(s): P. Janaki Pathi, N. Appala Raju, G.Parvathalu

DOI:         Access: Open Access Read More

Author(s): Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain

DOI: 10.5958/2231-5675.2015.00025.3         Access: Open Access Read More

Author(s): B. Thangabalan, M. Salomi, N. Sunitha, S. Manohar Babu

DOI:         Access: Open Access Read More

Author(s): Sri Lakshmi D, Jane T Jacob, Srinivasa Sastry D, Satyanarayana D

DOI: 10.5958/2231-5675.2017.00005.9         Access: Open Access Read More

Author(s): Shobha Rani G, Lohita M, Jaya Preethi P, Madhavi R, Sunisitha B, Mounika D

DOI:         Access: Open Access Read More

Author(s): Samer Housheh, Saleh Trefi, M. Fawaz Chehna

DOI: 10.5958/2231-5675.2017.00010.2         Access: Open Access Read More

Author(s): Hamid Khan, Mushir Ali, Alka Ahuja, Javed Ali

DOI:         Access: Open Access Read More

Author(s): Jayshree Pawar, Sandeep Sonawane, Santosh Chhajed, Sanjay Kshirsagar

DOI: 10.5958/2231-5675.2016.00024.7         Access: Open Access Read More

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 

Popular Articles


Recent Articles




Tags