Author(s): Patel Samixa R., Patel Chhaganbhai N.

Email(s): samixa.patel@gmail.com , samixa.patel@yahoo.co.in

DOI: Not Available

Address: Patel Samixa R.1*, Patel Chhaganbhai N.2
1School of Pharmacy, RK University, Rajkot, Gujarat India
1Atmiya Institute of Pharmacy, Department of Pharmaceutical Chemistry, “Yogidham Gurukul”, Kalawad Road, Rajkot-360005, Gujarat India.
2Shri Sarvajanik Pharmacy College, Mehsana, 384001, Gujarat India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 4,     Year - 2014


ABSTRACT:
A simple, accurate, precise, economical and reproducible method was developed for simultaneous estimation of aliskiren, amlodipine and hydrochlorothiazide in Combined Pharmaceutical Dosage Forms. The excipients in the commercial tablet preparation did not interfere with the assay. The ?max for aliskiren, amlodipine and hydrochlorothiazide were 252 nm, 360 nm and 271 nm respectively. At 360 nm, Amlodipine showed some absorbance while aliskiren and hydrochlorothiazide showed zero absorbance so that amlodipine was estimated at 360 nm. While at 252 nm and 271 nm aliskiren and hydrochlorothiazide were determine by simultaneous estimation method after eliminating the absorbent of Amlodipine at this wavelength. Linearity in concentration range of 4-28 µg/mL, 4-28 µg/mL and 20 - 120 µg/mL with The mean recoveries were 99.97 ± 0.82, 99.93 ± 0.88 and 100.14 ± 0.81 % for ALK, AML and HTZ, respectively. Validation of the proposed method was carried out according to ICH guidelines. Thus the present study gives an excellent method for the determination of all the three drugs in combined dosage formulation without their prior separation


Cite this article:
Patel Samixa R., Patel Chhaganbhai N.Development and Validation of Spectrophotometric Method for Determination of Aliskiren, Amlodipine and Hydrochlorothiazide in combined Pharmaceutical Dosage Forms. Asian J. Pharm. Ana. 4(4): Oct. - Dec. 2014; Page 162-167.


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