Author(s):
Jayesh D. Patil, Amitkumar R. Dhankani, Sunil P. Pawar
Email(s):
patiljayesh314@gmail.com
DOI:
10.52711/2231-5675.2023.00043 
Address:
Jayesh D. Patil*, Amitkumar R. Dhankani, Sunil P. Pawar
Department of Quality Assurance, Poojya Sane Guruji Vidya Prasarak Mandal, Shahada, Dist. Nandurbar, 425409, (MS), India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 4,
Year - 2023
ABSTRACT:
Non-steroidal anti-inflammatory drugs are the common and novel category of drugs which are widely used for the treatment of pain, inflammation and fever. NSAIDs inhibit the synthesis prostaglandins by the action on the cyclooxygenase enzymes. This review revealed the analytical method reported in literature for the determination of zaltoprofen, loxoprofen, ketoprofen, and flurbiprofen in pharmaceutical formulations in alone and combinations with other drugs. The comparison of twenty one analytical methods, including HPLC, UV-Spectrophotometry, and bioanalytical procedures, is most effectively illustrated in this comprehensive overview. To produce trustworthy data for regulatory filings, analytical development needs to be tested. A revolution in human health was brought about by the development of pharmaceuticals.
Cite this article:
Jayesh D. Patil, Amitkumar R. Dhankani, Sunil P. Pawar. Spectrophotometric and Chromatographic Review on NSAIDs include: Zaltoprofen, Loxoprofen, Ketoprofen and Flurbiprofen. Asian Journal of Pharmaceutical Analysis. 2023; 13(4):261-6. doi: 10.52711/2231-5675.2023.00043
Cite(Electronic):
Jayesh D. Patil, Amitkumar R. Dhankani, Sunil P. Pawar. Spectrophotometric and Chromatographic Review on NSAIDs include: Zaltoprofen, Loxoprofen, Ketoprofen and Flurbiprofen. Asian Journal of Pharmaceutical Analysis. 2023; 13(4):261-6. doi: 10.52711/2231-5675.2023.00043 Available on: https://ajpaonline.com/AbstractView.aspx?PID=2023-13-4-7
REFERENCE:
1. Syed, M., Skonberg, C. and Hansen, S.H. Inhibition of ATP synthesis by fenbufen and its conjugated metabolites in rat liver mitochondria. Toxicology in Vitro. 2016; 31: 23-29.
2. Martın, M.J., Pablos, F. and Gonzalez, A.G. Simultaneous determination of caffeine and non-steroidal anti-inflammatory drugs in pharmaceutical formulations and blood plasma by reversed-phase HPLC from linear gradient elution. Talanta. 1999; 49(2): 453-459.
3. Shah, P.P., Desai, P.R. and Singh, M. Effect of oleic acid modified polymeric bilayered nanoparticles on percutaneous delivery of spantide II and ketoprofen. Journal of Controlled Release. 2012; 158(2): 336-345.
4. Ejaz, P., K. Bhojani, and V. R. Joshi. 2004. NSAIDs and kidney. Japi 52, pp. 632-640.
5. Varshney, H.M. and Chatterjee. Formulation, evaluation and in-vitro release characteristics of zaltoprofen suppositories. Asian J. Pharm. Clin. Res. 2012; 5(4): 235.
6. Loya, P., Kshatriya, A.A. and Saraf, M.N., 2011. Bioequivalence study of two brands of loxoprofen tablets in healthy volunteers. Int J PharmTech Research, 3(4), pp.2038-2046.
7. El-Kafrawy, D.S., Abo-Gharam, A.H., Abdel-Khalek, M.M., Mahrous, M.S. and Belal, T.S., 2018. Spectrophotometric estimation methods for loxoprofen sodium based on charge transfer complexation reactions. Research Journal of Pharmaceutical Biological and Chemical Sciences. 2018; 9(2); 669-681.
8. Azeez, A.M. and Fakhre, N.A. Determination of ketoprofen in tablet dosage forms by derivative IR spectroscopy. Egyptian Journal of Chemistry. 2022; 65(1): 215-219.
9. Kantor, T.G., 1986. Ketoprofen: a review of its pharmacologic and clinical properties. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 1986; 6(3): 93-102.
10. Maroof, K., Zafar, F., Ali, H. and Naveed, S., 2015. Flurbiprofen: a potent pain reliever. J Bioequiv Availab. 2015; 7(1): 56-58.
11. Akash, M.S.H., Rehman, K., Akash, M.S.H. and Rehman, K., 2020. Ultraviolet-visible (UV-VIS) spectroscopy. Essentials of Pharmaceutical Analysis, pp. 29-56.
12. Aher, K.B., Bhavar, G.B., Chaudhari, S.R. and Joshi, H.P. Economical spectrophotometric method for estimation of zaltoprofen in pharmaceutical formulations. Pharmaceutical Methods. 2011; 2(2): 152-156.
13. Patel, C.D., Sen, A.K., Sen, D.B., Sahoo, U. and Seth, A.K. Analytical method development and validation of UV spectroscopic method for simultaneous estimation of zaltoprofen and paracetamol in combined dosage form. Pharma Science Monitor. 2014; 5(3): 59-70.
14. Zahira, N.K. and Prasannakumaran, P.N. Analytical method development and validation of zaltoprofen and paracetamol in combined dosage form by ultraviolet spectrophotometry. International Journal of Pharmaceutical Sciences and Research. 2015; 6(2): 682.
15. Kalamkar, R.V., Wadher, S.J., Gagare, S.S. and Jain, A.S. Development and Validation of UV Spectroscopic Methods for Simultaneous Estimation of Paracetamol and Zaltoprofen in bulk and tablet formulation. International Journal of Pharmaceutical Sciences and Research. 2015; 6(2): 717.
16. Bhardwaj, S.K., Dwivedia, K. and Agarwala, D.D. A review: HPLC method development and validation. International Journal of Analytical and Bioanalytical Chemistry. 2015; 5(4): 76-81.
17. Kumar, T.M., Srikanth, G., Pamulaparthya, V., Rao, J.V. and Raod, K.S. Development and validation of HPLC-UV method for the estimation of zaltoprofen in human plasma. Journal of Pharmacy Research. 2011; 4(10): 3753-3755.
18. Kim, K.T., Kim, S.H., Lee, W., Lee, K.C., Lee, Y.K., Park, K.R., Jung, S.H. and Kang, J.S. Chiral pharmacokinetics of zaltoprofen in rats by HPLC with solid-phase extraction. Journal of Pharmaceutical and Biomedical Analysis. 2012; 70: 567-573.
19. Kumar, E.G. Development and validation of stability indicating RP-HPLC method for the determination of Zaltoprofen, a potent NSAID. IJAPR. 2014; 5(12): 429 – 435.
20. Yang, H.K., Kim, S.Y., Kim, J.S., Sah, H. and Lee, H.J., 2009. Application of column‐switching HPLC method in evaluating pharmacokinetic parameters of zaltoprofen and its salt. Biomedical Chromatography. 2009; 23(5): 537-542.
21. Patel, D., Patel, J.G. and Patel, B.R. Analytical method development and validation of stability indicating RPHPLC method for estimation of paracetamol and zaltoprofen in tablet. International Journal of Research and Analytical Reviews. 6(2).
22. Farooq, M., Shoaib, M.H., Yousuf, R.I., Siddiqui, F., Hanif, M., Naz, S. and Bashir, L. Development and validation of liquid chromatographic method for quantitative determination of Loxoprofen in mobile phase and in human plasma. Pakistan Journal of Pharmaceutical Sciences. 2018; 31(6): 2629-2633.
23. Kashif, M., Nisar-Ur-Rahman, Idrees, H.A., Aslam, I., Iqbal, S.M. and Mustafa, R., 2013. HPL-UV detection method for quantification of loxoprofen in human plasma with liquid-liquid extraction technique: Application in pharmacokinetic study. Latin American Journal of Pharmacy. 2013; 32(4): 587-592.
24. Choo, K.S., Kim, I.W., Jung, J.K., Suh, Y.G., Chung, S.J., Lee, M.H. and Shim, C.K. Simultaneous determination of loxoprofen and its diastereomeric alcohol metabolites in human plasma and urine by a simple HPLC-UV detection method. Journal of pharmaceutical and biomedical analysis. 2001; 25(3-4): 639-650.
25. Negru, J., Popa, D.S., Vlase, L., Iacob, D., Achim, M. and Dorneanu, V. High-throughput hplc method for rapid quantification of ketoprofen in human plasma. Farmacia. 2015; 63(5): 770-5.
26. Tsvetkova, B. and Peikova, L. HPLC determination of ketoprofen in tablet dosage forms. Trakia J. Sci .2013; 11: 55.
27. Yadav, N.K., Raghuvanshi, A., Sharma, G., Beg, S., Katare, O.P. and Nanda, S. QbD-based development and validation of a stability-indicating HPLC method for estimating ketoprofen in bulk drug and proniosomal vesicular system. Journal of Chromatographic Science. 2016; 54(3): 377-389.
28. Wankhede, S.B., Zambare, S.S., Dixit, N.R. and Chitlange, S.S. RP-HPLC method for simultaneous estimation of thiocolchicoside and ketoprofen in combined dosage form. Der Pharmacia Lettre. 2010; 2(3): 315-320.
29. Yilmaz, B., Bayrak, B. and Kadioğlu, Y., Development and Validation of HPLC Method for the Determination of Flurbiprofen in Pharmaceutical Preparations. International Journal of Pharm Ata. 2(3): 1-10.
30. Akhlaq, M., Khan, G.M., Wahab, A., Khan, A., Hussain, A., Nawaz, A. and Abdelkader, H. A simple high-performance liquid chromatographic practical approach for determination of flurbiprofen. Journal of Advanced Pharmaceutical Technology and Research. 2011; 2(3): 151.
31. Han, F., Yin, R., Shi, X.L., Jia, Q., Liu, H.Z., Yao, H.M., Xu, L. and Li, S.M. Cloud point extraction-HPLC method for determination and pharmacokinetic study of flurbiprofen in rat plasma after oral and transdermal administration. Journal of Chromatography B. 2008; 868(1-2): 64-69.
32. Aminu, N., Chan, S.Y. and Toh, S.M. Development and validation of a stability-indicating HPLC-UV method for the simultaneous determination of flurbiprofen and triclosan in dental nanogel formulations. Journal of Physical Science. 2018; 29: 1-7.
33. Hanif, M., Nazir, N., Zia, M.U., Chudhary, B.A., Abbas, G., Rana, S.J. and Zaman, M. Development of high performance liquid chomatography method for determination of flurbiprofen and ranitidine in bilayer tablets. Lat. Am. J. Pharm. 2015; 34(9): 1737-1742.