Author(s): Ajay I Patel, Jenish Rachhadiya, Purvi Vadariya, Amitkumar J. Vysh, Ashok B. Patel


DOI: 10.52711/2231-5675.2022.00044   

Address: Ajay I Patel, Jenish Rachhadiya, Purvi Vadariya, Amitkumar J. Vysh, Ashok B. Patel
Tapan Heights, C-304, Near Matuki Restaurent 80 Feet Ring Road, Vavdi Rajkot - 04 Gujarat.
*Corresponding Author

Published In:   Volume - 12,      Issue - 4,     Year - 2022

Diabetes mellitus both type I and type II, is a dangerous and lifelong disorder marked by unusually high blood glucose levels caused by a failure of insulin synthesis or a loss in insulin sensitivity and function. Diabetes have become more common over time, and it is now considered one of the primary causes of high death and morbidity rates. Complications from diabetes can be avoided by regularly monitoring and keeping blood glucose levels within the normal range. Despite the fact that practically all commercially effective blood glucose monitoring devices are invasive, there is an urgent need to create non-invasive glucose monitoring (NGM) devices that would relieve diabetics' pain and suffering associated with repeated skin pricking for glucose testing. It also discusses the most common non-invasive glucose monitoring technologies as well as the most relevant devices. The technology name, the underlying physical principle, and the technological limitation in the human body. There are eleven technologies and five devices in all. Despite numerous fascinating and promising ideas and devices, the review concluded that a suitable solution to the non-invasive glucose monitoring problem still required more work.

Cite this article:
Ajay I Patel, Jenish Rachhadiya, Purvi Vadariya, Amitkumar J. Vysh, Ashok B. Patel. A Critical Review on Current Devloping Non-Invasive Glucose Monitoring Technologies and Devices. Asian Journal of Pharmaceutical Analysis. 2022; 12(4):264-0. doi: 10.52711/2231-5675.2022.00044

Ajay I Patel, Jenish Rachhadiya, Purvi Vadariya, Amitkumar J. Vysh, Ashok B. Patel. A Critical Review on Current Devloping Non-Invasive Glucose Monitoring Technologies and Devices. Asian Journal of Pharmaceutical Analysis. 2022; 12(4):264-0. doi: 10.52711/2231-5675.2022.00044   Available on:

1.    Tan SY, Mei Wong JL, Sim YJ, et al. Type 1 and 2 diabetes mellitus: A review on current treatment approach and gene therapy as potential intervention. Diabetes Metab Syndr Clin Res Rev. 2019;13(1): 364-372. doi:10.1016/j.dsx.2018.10.008
2.    Ferrante do Amaral CE, Wolf B. Current development in non-invasive glucose monitoring. Med Eng Phys. 2008;30(5):541-549. doi:10.1016/j.medengphy.2007.06.003
3.    Rajput R, Agrawal J, Sharma S, Scholar CSE Mt. A Literature Survey of Different Type Diabetes Mellitus Detection Analysis. J Comput Technol. 2021; (02): 1-7.
4.    Lin X, Xu Y, Pan X, et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Sci Rep. 2020;10(1):1-11. doi:10.1038/s41598-020-71908-9
5.    So CF, Choi KS, Wong TKS, Chung JWY. Recent advances in noninvasive glucose monitoring. Med Devices Evid Res. 2012; 5(1): 45-52.
6.    Mosli H, Madani B. Performance evaluation of egm1000™ non-invasive glucose monitoring device in patients with type 2 diabetes and subjects with prediabetes. Int J Med Dev Ctries. 2021;5(March):1020-1028. doi:10.24911/ijmdc.51-1611360395
7.    Kalaiselvi P, Anand M, Sivaguru K, Deepak S. Continuous Blood Glucose Monitoring Using Non Invasive Technique. 2016;1(4):142-147.
8.    Arnold MA. Non-invasive glucose monitoring.
9.    Potts RO, Tamada JA, Tierney MJ. Glucose monitoring by reverse iontophoresis. Diabetes Metab Res Rev. 2002;18(SUPPL. 1):49-53. doi:10.1002/dmrr.210
10.    Leboulanger B, Guy RH, Delgado-Charro MB. Reverse iontophoresis for non-invasive transdermal monitoring. Physiol Meas. 2004;25(3). doi:10.1088/0967-3334/25/3/R01
11.    Tura A, Maran A, Pacini G. Non-invasive glucose monitoring: Assessment of technologies and devices according to quantitative criteria. Diabetes Res Clin Pract. 2007;77(1):16-40. doi:10.1016/j.diabres.2006.10.027
12.    Pitzer KR, Desai S, Dunn T, et al. Detection of Hypoglycemia with the GlucoWatch Biographer. Diabetes Care. 2001;24(5):881-885. doi:10.2337/diacare.24.5.881
13.    Maruo K, Tsurugi M, Chin J, et al. Noninvasive blood glucose assay using a newly developed near-infrared system. IEEE J Sel Top Quantum Electron. 2003;9(2):322-330. doi:10.1109/JSTQE.2003.811283
14.    Yadav J, Rani A, Singh V, Murari BM. Prospects and limitations of non-invasive blood glucose monitoring using near-infrared spectroscopy. Biomed Signal Process Control. 2015;18:214-227. doi:10.1016/j.bspc.2015.01.005
15.    Monnier VM, Bautista O, Kenny D, et al. as Markers of Diabetic Complications. Diabetes. 1999;48(April):870-880.
16.    Oomen PHN, Kant GD, Dullaart RPF, Reitsma WD, Smit AJ. Acute hyperglycemia and hyperinsulinemia enhance vasodilatation in type 1 diabetes mellitus without increasing capillary permeability and inducing endothelial dysfunction. Microvasc Res. 2002;63(1):1-9. doi:10.1006/mvre.2001.2347
17.    Kasahara R, Kino S, Soyama S, Matsuura Y. Noninvasive glucose monitoring using mid-infrared absorption spectroscopy based on a few wavenumbers. Biomed Opt Express. 2018;9(1):289. doi:10.1364/boe.9.000289
18.    Sobel SI, Chomentowski PJ, Vyas N, Andre D, Toledo FGS. Accuracy of a novel noninvasive multisensor technology to estimate glucose in diabetic subjects during dynamic conditions. J Diabetes Sci Technol. 2014;8(1):54-63. doi:10.1177/1932296813516182
19.    Vashist SK. Non-invasive glucose monitoring technology in diabetes management: A review. Anal Chim Acta. 2012;750:16-27. doi:10.1016/j.aca.2012.03.043
20.    Öz G, Seaquist ER, Kumar A, et al. Human brain glycogen content and metabolism: Implications on its role in brain energy metabolism. Am J Physiol - Endocrinol Metab. 2007;292(3). doi:10.1152/ajpendo.00424.2006
21.    Aslan K, Leonenko Z, Lakowicz JR, Geddes CD. Annealed silver-island films for applications in metal-enhanced fluorescence: Interpretation in terms of radiating plasmons. J Fluoresc. 2005;15(5):643-654. doi:10.1007/s10895-005-2970-z
22.    Moschou EA, Sharma B V., Deo SK, Daunert S. Fluorescence glucose detection: Advances toward the ideal in vivo biosensor. J Fluoresc. 2004;14(5):535-547. doi:10.1023/B:JOFL.0000039341.64999.83
23.    March W, Lazzaro D, Rastogi S. Fluorescent measurement in the non-invasive contact lens glucose sensor. Diabetes Technol Ther. 2006;8(3):312-317. doi:10.1089/dia.2006.8.312
24.    Hillier TA, Abbott RD, Barrett EJ. Hyponatremia: Evaluating the correction factor for hyperglycemia. Am J Med. 1999;106(4):399-403. doi:10.1016/S0002-9343(99)00055-8
25.    Polevaya Y, Ermolina I, Schlesinger M, Ginzburg BZ, Feldman Y. Time domain dielectric spectroscopy study of human cells II. Normal and malignant white blood cells. Biochim Biophys Acta - Biomembr. 1999;1419(2):257-271. doi:10.1016/S0005-2736(99)00072-3
26.    Jang S, Fox MD. Optical Glucose Sensor Using a Single Faraday Rotator Sunghoon Jang and Martin D. Fox Department of Electrical and Systems Engineering University of Connecticut, Storrs Ct. 06269. Bioengineering. 1997;(2):11-12.
27.    Larin K V., Eledrisi MS, Motamedi M, Esenaliev RO. Noninvasive blood glucose monitoring with optical coherence tomography: A pilot study in human subjects. Diabetes Care. 2002;25(12):2263-2267. doi:10.2337/diacare.25.12.2263
28.    Domschke A, March WF, Kabilan S, Lowe C. Initial clinical testing of a holographic non-invasive contact lens glucose sensor. Diabetes Technol Ther. 2006;8(1):89-93. doi:10.1089/dia.2006.8.89
29.    Srivastava A, Chowdhury MK, Sharma S, Sharma N. Blood Glucose Monitoring Using Non Invasive Optical Method: Design Limitations and Challenges. Int J Adv Res Electr Electron Instrum Eng. 2013;2(1):615-620.
30.    Baca JT, Taormina CR, Feingold E, Finegold DN, Grabowski JJ, Asher SA. Mass spectral determination of fasting tear glucose concentrations in nondiabetic volunteers. Clin Chem. 2007; 53(7):1370-1372. doi:10.1373/clinchem.2006.078543
31.    Cameron BD, Baba JS, Coté GL. Measurement of the glucose transport time delay between the blood and aqueous humor of the eye for the eventual development of a noninvasive glucose sensor. Diabetes Technol Ther. 2001;3(2):201-207. doi:10.1089/152091501300209552
32.    Al-Qaisi MK, Wang H, Akkin T. Measurement of Faraday rotation using interferometry. Appl Opt. 2009;48(30):5829-5833.
33.    Ergin A, Thomas GA. Non-invasive detection of glucose in porcine eyes. Proc IEEE Annu Northeast Bioeng Conf NEBEC. Published online 2005:246-247. doi:10.1109/nebc.2005.1432012
34.    Ellis DI, Goodacre R. Metabolic fingerprinting in disease diagnosis: Biomedical applications of infrared and Raman spectroscopy. Analyst. 2006; 131(8): 875-885. doi:10.1039/b602376m
35.    Lee S, Nayak V, Dodds J, Pishko M, Smith NB. Glucose measurements with sensors and ultrasound. Ultrasound Med Biol. 2005; 31(7):971-977. doi:10.1016/j.ultrasmedbio.2005.04.004
36.    Merino V, López A. Transdermal Iontophoresis. Curr Technol to Increase Transdermal Deliv Drugs. Published online 2010:41-52. doi:10.2174/978160805191511001010041
37.    Tierney MJ, Tamada JA, Potts RO, Jovanovic L, Garg S. Clinical evaluation of the GlucoWatch® biographer: A continual, non-invasive glucose monitor for patients with diabetes. Biosens Bioelectron. 2001;16(9-12):621-629. doi:10.1016/S0956-5663(01)00189-0
38.    Harman-Boehm I, Gal A, Raykhman AM, Zahn JD, Naidis E, Mayzel Y. Noninvasive glucose monitoring: A novel approach. J Diabetes Sci Technol. 2009;3(2):253-260. doi:10.1177/193229680900300205
39.    Gonzales WV, Mobashsher AT, Abbosh A. The Progress of Glucose Monitoring—A Review of Invasive to Minimally and Non-Invasive Techniques, Devices and Sensors. Vol 19.; 2019. doi:10.3390/s19040800
40.    Portable thickness gauge - CMI 255 - Hitachi High-Tech Analytical Science - coating / eddy current / magnetic induction. Accessed February 17, 2022.
41.    GlucoTrack | Your track to health!.TM. Accessed February 17, 2022.

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Author(s): Ajay I Patel, Jenish Rachhadiya, Purvi Vadariya, Amitkumar J. Vysh, Ashok B. Patel

DOI: 10.52711/2231-5675.2022.00044         Access: Closed Access Read More

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