ABSTRACT:
A Dipeptidyl peptidase-4 inhibitor teneligliptin hydrobromide is used for lowering blood glucose levels in people with diabetes mellitus. A very straight forward, quick, responsive and accurate UV- Spectrophotometric method of analysis have been developed for assessment of Teneligliptin Hydrobromide in pharmaceutical formulation. Since teneligliptin hydrobromide only absorbs UV in the low wavelength area, it cannot be identify with high sensitivity. Teneligliptin Hydrobromide has shown successful results for various analytical instruments only in the permutation of Taurine and Sodium periodate. The API was derivatives using Taurine and Sodium periodate in water and methanol. Drug exhibited distinct ?max in methanol at 281nm. Linearity was observed in the concentration range 10-80 µg/ml. The method was validated by recovery studies. The methods used are inexpensive and sensitive for the inference of teneligliptin hydrobromide in bulk drug and tablet dosage forms.
Cite this article:
Kalyani Farkade, Mukund Tawar. Analytical Method Validation and Quantitative Analysis for Active Pharmaceutical Ingredient and Marketed Formulation of Teneligliptin Hydrobromide by UV Spectroscopy. Asian Journal of Pharmaceutical Analysis. 2021; 11(3):195-8. doi: 10.52711/2231-5675.2021.00034
Cite(Electronic):
Kalyani Farkade, Mukund Tawar. Analytical Method Validation and Quantitative Analysis for Active Pharmaceutical Ingredient and Marketed Formulation of Teneligliptin Hydrobromide by UV Spectroscopy. Asian Journal of Pharmaceutical Analysis. 2021; 11(3):195-8. doi: 10.52711/2231-5675.2021.00034 Available on: https://ajpaonline.com/AbstractView.aspx?PID=2021-11-3-4
REFERENCES:
1. Rotimi C, Daniel H, Zhou J, Obisesan A, Chen G, Chen Y, Amoah A, Opoku V, Acheampong J, Agyenim-Boateng K, Eghan Jr BA. Prevalence and determinants of diabetic retinopathy and cataracts in West African type 2 diabetes patients.
2. Gautam R, Sharma SC. Effect of Punica granatum Linn. (peel) on blood glucose level in normal and alloxan-induced diabetic rats. Research Journal of Pharmacy and Technology. 2012; 5(2): 226-7.
3. Divya N, Ilavenil S. Hypoglycemic and Hypolipidemic Potentials of Psidium guajava in Alloxan Induced Diabetic Rats. Research Journal of Pharmacy and Technology. 2012; 5(1): 125-8.
4. Bhutkar MA, Bhise SB. Spices and condiments in the management of diabetes mellitus. Research Journal of Pharmacy and Technology. 2011; 4(1): 37-42.
5. Ravishankar A. Treatment of Diabetes Insipidus. Research Journal of Pharmacy and Technology. 2015 Jun 29; 8(6): 767-71.
6. Kishimoto M. Teneligliptin: a DPP-4 inhibitor for the treatment of type 2 diabetes. Diabetes, metabolic syndrome and obesity: targets and therapy. 2013; 6: 187.
7. Kamala M, Banu MS, Senthil R, Anand AV. Anti–Hyperglycemic and Anti–Hyperlipidemic Potentials of Psidium guajava Fruit Extract–a Review. Research Journal of Pharmacy and Technology. 2011; 4(7): 1033-6.-103.
8. Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian journal of pharmaceutical education and research. 2021 Jan 1; 55(1): 86-94.
9. Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co-Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18; 14(3): 1535-41.
10. Mythili K, Gayatri S, Kumar EM, Reddy TA, Chitra K, Reddy C. Development and validation of UV spectrophotometric method for the estimation of strontium ranelate in sachet formulation. Research Journal of Pharmacy and Technology. 2011; 4(9): 1468-70.
11. Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019; 12(12): 5972-6.
12. Sharma. B.K, Instrumental method of chemical analysis, 18th edition, Krishna prakashan media (P) Ltd., Meerut, 1999, Pp. No. 39-139.
13. Vogel AI, Jeffery GH. Vogel's textbook of quantitative chemical analysis. Wiley; 1989.
14. Goda M, Kadowaki T. Teneligliptin for the treatment of type 2 diabetes. Drugs of today (Barcelona, Spain: 1998). 2013 Oct; 49(10): 615.
15. Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31; 13(1): 4745-52.
16. Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31; 13(3): 4942-51.
17. Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019; 8(8): 624-9.
18. Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020; 6(2): 94-100.
19. Shah R, Magdum C, Patil SK, Chougule DK, Naikwade N. Validated spectroscopic method for estimation of aceclofenac from tablet formulation. Research Journal of Pharmacy and Technology. 2008; 1(4): 430-2.
20. Nimje HM, Oswal RJ, Kshirsagar SS, Chavan M. Spectrophotometric Analysis for Estimation of Felodipine in Tablet Dosage Form by Calibration Curve Method. Research Journal of Pharmacy and Technology. 2011; 4(12): 1805-6.