Author(s): Prajakta D. Mhaske, Burhan A. Bohari, Suraj R. Chaudhari, Pritam S. Jain, Atul A. Shirkhedkar

Email(s): shirkhedkar@gmail.com

DOI: 10.5958/2231-5675.2020.00015.0   

Address: Prajakta D. Mhaske1, Burhan A. Bohari2, Suraj R. Chaudhari1, Pritam S. Jain1, Atul A. Shirkhedkar1*
1Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, (MS) 425405
2Department of Pharmaceutical Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, (MS) 425405
*Corresponding Author

Published In:   Volume - 10,      Issue - 2,     Year - 2020


ABSTRACT:
A validated sensitive and accurate zero-order area under curve spectrophotometric method was adopted for analysis of tamsulosin hydrochloride in pure form and pharmaceutical dosage form. The area of peak was measured in the wavelength range of 220-227.60 nm by dissolving pure drug and dilution was made in a mixture of methanol and water (30:70 %). Linearity plot was constructed and linearity was followed in the concentration range of 5-35 µg/mL with correlation coefficient (r2) 0.997. The developed method was successfully implemented for the determination of tamsulosin hydrochloride in pharmaceutical preparation and amount of analyte was estimated was found to be 98.53 ± 0.62 %. The results obtained indicate no interference from excipients present in pharmaceutical preparation. Moreover, the present work was validated statistically with respect to the accuracy, precision,the limit of detection and of quantification and ruggedness. The result of all parameters was analysed and indicated that the established method can be classified amongst highly sensitive and accurate procedure. Moreover, the established method was compared with the reported method. These merits suggested the use of the proposed method in routine and quality control analysis of tamsulosin hydrochloride without the interference of common excipients in a dosage form. Further, the established method is validated as per international conference on harmonization guidelines.


Cite this article:
Prajakta D. Mhaske, Burhan A. Bohari, Suraj R. Chaudhari, Pritam S. Jain, Atul A. Shirkhedkar. Implementation UV-Spectrophotometry approach for Determination of Tamsulosin HCl in tablets using area under Curve Technique. Asian J. Pharm. Ana. 2020; 10(2): 86-90. doi: 10.5958/2231-5675.2020.00015.0


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DOI: 10.5958/2231–5675 

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