Author(s): A. Sureka, R. Dhanalakshmi, C. Mary Sharmila, R. Chithra Devi

Email(s): eva.sureka@gmail.com

DOI: 10.5958/2231-5675.2019.00019.X   

Address: A. Sureka1, R. Dhanalakshmi2, C. Mary Sharmila3, R. Chithra Devi4
1Emergency Medical Officer, National Institute of Siddha, Tambaram Sanatorium, Chennai 600047,Tamil Nadu, India. 2Medical Officer, Naturalife Hospital, Thrichy, Tamil Nadu, India.
3 Resident Medical Officer, National Institute of Siddha, Tambaram Sanatorium, Chennai 600047,Tamil Nadu, India.
4House Officer, National Institute of Siddha, Tambaram Sanatoruim, Chennai 600047, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 9,      Issue - 2,     Year - 2019


ABSTRACT:
Standardization is an integral part of the medicine system, which began since several centuries. The great Siddhars of the siddha system of medicine has Clearly documented both the preparation techniques and treatment methodology for each class of disease and their therapy. Siddha medicinal formulations has multiple components hence it’s involves greater challenge in standardization of the same. The standardization of herbal preparations can be achieved by systematic procedures. Manosilai is a metallo mineral drug composed of arsenic and sulphur as major components. According to siddha principle metals and minerals possess enormous healing properties as it can mediate some of the biologically significant metabolic reactions in the human body. Also it is utmost important to establish a detailed monograph of such preparation as a standard for future researchers who work on this novel formulation. The main aim of the present study is to comparatively analyze the siddha drug manosilai (MS) with special reference to its purification process by modern sophisticated analytical instrumentation techniques such as Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and X-ray powder diffraction (XRD). From the results of the present investigation it was observed that there was slight change in LOD value of the sample manosilai before purification (MSBP) and after purification (MSAP). In which the total ash value remains the same. There is no significant change were observed in the water soluble extractive value of both the sample. But there was marginal difference in alcohol soluble extractive value and pH of the samples MSBP and MSAP. FT-IR spectral data’s signifies the presence of increased functional group in the MSAP when compare to that of the MSBP. In which the sample MSBP depicts the presence of S=O and NH functional groups which were absent in MSAP. Whereas the sample MSAP has shown the presence of additional functional groups id N-N=O, C-Br and other benzyl groups were not observed in MSBP. There was no significant changes were observed with respect to the surface morphology and also average particle size of the both of these samples MSBP and MSAP. It was observed from the result analysis of the X-RD pattern of the sample MS before and after purification shows no significant change in the elemental composition since in both the preparations arsenic and sulphur remains the core components.


Cite this article:
A. Sureka, R. Dhanalakshmi, C. Mary Sharmila, R. Chithra Devi. Comparative Analysis on Significance of Purification Process of Monosilai in Siddha medicine using Modern Instrumental Techniques: Standardization Approach. Asian J. Pharm. Ana. 2019; 9(2):99-104. doi: 10.5958/2231-5675.2019.00019.X


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DOI: 10.5958/2231–5675 

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