Author(s): Ahmed G. Helmy, Fatma M. Abdel-Gawad, Eman F. Mohamed

Email(s): fatmagawad@gmail.com

DOI: Not Available

Address: Ahmed G. Helmy1, Fatma M. Abdel-Gawad2*and Eman F. Mohamed2
1Physical Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
2National Organization for Drug Control and Research (NODCAR), 6-Abu-Hazem St., Pyramids Ave, P.O. Box 29, 35521 Giza, Egypt.
*Corresponding Author

Published In:   Volume - 2,      Issue - 1,     Year - 2012


ABSTRACT:
Two accurate, simple and sensitive spectrophotometric methods have been described for the assay of aripiprazole either in bulk substances or in tablets. The first method was based on the charge-transfer reaction of the drug as an n-electron donor with either 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as p-acceptor or iodine (I2) as s-acceptor to give highly colored complexes. The absorbance of products was measured at 457 nm in acetonitrile and 364 nm in 1,2-dichloroethane for DDQ and I2 methods, respectively. The second method was based on the formation of ion-pair complexes with the acidic sulphonephthalein dyes bromocresol green (BCG) and bromocresol purple (BCP). The color absorbance was measured at 413 and 400 nm in 1,2-dichloroethane for BCG and BCP, respectively. Under the optimum reaction conditions, Beer’s law was obeyed with good correlation coefficients (r= 0.9997-0.9999) in the concentration ranges 10-120, 2-28, 2-24 and 2-20 µg mL-1 of drug for DDQ, I2, BCG and BCP methods, respectively. Spectral characteristics and stability constants of the formed ion associates are discussed in terms of the nature of donor and acceptor molecular structures. The proposed methods were successfully applied for determination of the drug in tablets with good accuracy and precision.


Cite this article:
Ahmed G. Helmy, Fatma M. Abdel-Gawad, Eman F. Mohamed. Spectrophotometric Study on Determination of Aripiprazole in Tablets by Charge-Transfer and Ion-Pair Complexation Reactions with Some Acceptors. Asian J. Pharm. Ana. 2(1): Jan.-Mar. 2012; Page 12-19.


Recomonded Articles:

Author(s): Asha M. Jagtap, Sudhir R. Kaulage, Shivam S. Kanse, Vishal D. Shelke, Akshata S. Gavade, Ganesh B. Vambhurkar, Rohit R. Todkar, Vidya N. Dange

DOI: 10.5958/2231-5675.2018.00035.2         Access: Open Access Read More

Author(s): K. Pramod, Shahid H. Ansari, Javed Ali

DOI:         Access: Open Access Read More

Author(s): Santosh Gada, Anand Kumar Y, Saritha, C. Mallikarjuna Setty

DOI: 10.5958/2231-5675.2018.00036.4         Access: Open Access Read More

Author(s): Sushil D. Patil, Sayali K. Chaure, Maswood Ahmed Hafizur Rahman, Prajkta U. Varpe, Sanjay Kshirsagar.

DOI: 10.5958/2231-5675.2017.00004.7         Access: Open Access Read More

Author(s): G. Krishnamoorthy, C. Diana Priyadarshini, R. Senthamarai

DOI:         Access: Open Access Read More

Author(s): Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain

DOI: 10.5958/2231-5675.2015.00025.3         Access: Open Access Read More

Author(s): Mansi J. Chaudhari, Suraj R. Chaudhari, Shailesh S. Chalikwar, Atul A. Shirkhedkar

DOI: 10.5958/2231-5675.2018.00008.X         Access: Open Access Read More

Author(s): Saroj Kumar Raul, Bukkuru Spandana, Patibandla Sameera, Vegiraju Vikitha

DOI:         Access: Open Access Read More

Author(s): S. Vidyadhara, RLC Sasidhar, B. Venkateswara Rao, P. Ratna Kumari

DOI:         Access: Open Access Read More

Author(s): Yogita R. Indalkar, Aloorkar N.H.

DOI: 10.5958/2231-5675.2015.00028.9         Access: Open Access Read More

Author(s): Shobha Rani G, Lohita M, Jaya Preethi P, Madhavi R, Sunisitha B, Mounika D

DOI:         Access: Open Access Read More

Author(s): Madhavi R., Mohana Krishna A., Shobha Rani G., Mounika D.

DOI: 10.5958/2231-5675.2015.00008.3         Access: Open Access Read More

Author(s): Saroj Kumar Raul, Gopal Krishna Padhy, Pramudula Ramya Krishna, Boddu Uma Madhu Priya

DOI:         Access: Open Access Read More

Author(s): Kathirvel S., Raju R., Seethadevi B., Suneetha A.,Jyothisree K.

DOI: 10.5958/2231-5675.2015.00014.9         Access: Open Access Read More

Author(s): K. Pramod, Shahid H. Ansari, Javed Ali

DOI:         Access: Open Access Read More

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 

Popular Articles


Recent Articles




Tags