Author(s): G. Rohit Reddy, T. Ramesh

Email(s): rohitreddy1610@gmail.com

DOI: 10.52711/2231-5675.2023.00038   

Address: G. Rohit Reddy*, T. Ramesh
Department of Pharmaceutical Analysis and Quality Assurance,
Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2023


ABSTRACT:
A simple, sensitive, accurate, precise and economical visible Spectrophotometric method was developed and validated for the estimation of Atorvastatin in Bulk form. The method is based on the reaction of Atorvastatin with MBTH Reagent [3-Methyl-2-Benzothiazolinone Hydrazone] in the presence of ferric chloride giving greenish blue colour chromogen which shows maximum absorbance at 566nm against reagent blank. The Chromogen obeyed Beer’s law in the concentration range of 5-25 µg/ml for Atorvastatin. The results of the analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method.


Cite this article:
G. Rohit Reddy, T. Ramesh. A New Colorimetric Development and Validation of Visible Method for Estimation of Atorvastatin in Bulk Formulation. Asian Journal of Pharmaceutical Analysis. 2023; 13(4):236-8. doi: 10.52711/2231-5675.2023.00038

Cite(Electronic):
G. Rohit Reddy, T. Ramesh. A New Colorimetric Development and Validation of Visible Method for Estimation of Atorvastatin in Bulk Formulation. Asian Journal of Pharmaceutical Analysis. 2023; 13(4):236-8. doi: 10.52711/2231-5675.2023.00038   Available on: https://ajpaonline.com/AbstractView.aspx?PID=2023-13-4-2


REFERENCES:
1.    United States Pharmacopeia 2020 Volume-I, USP 43, 414.
2.    https://pubchem.ncbi.nlm.nih.gov.
3.    Shyni Bernard and Molly Mathew-Spectrophotometric method of estimation of Atorvastatin using sulfo-phospho-vanillin reaction. Journal of Applied Pharmaceutical Science.
4.    Gowari Sankar D., Raju M S M., Sumanth, Kalyan S., Latha P-Estimation of Atorvastatin by high performance liquid chromatography in pure and pharmaceutical dosage form. Asian J. Chem. 2005; 17 (4): 2571.
5.    https://go.drugbank.com/drugs/DB01076.
6.    ICH Q2B, Text on Validation of Analytical Procedures. Geneva (1994) 1-5.

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DOI: 10.5958/2231–5675 


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