Author(s): Sruthikrishna P.K, Sapna Shrikumar

Email(s): sruthykrishna242@gmail.com

DOI: 10.52711/2231-5675.2022.00022   

Address: Sruthikrishna P.K1*, Sapna Shrikumar2
1Student, Department of Pharmacognosy and Phytochemistry, Research Laboratory, Nehru College of Pharmacy, Pampady, Thiruvilwamala, Thrissur-680588, Kerala, India.
2Head of the Department, Department of Pharmacognosy and Phytochemistry, Research Laboratory, Nehru College of Pharmacy, Pampady, Thiruvilwamala, Thrissur-680588, Kerala, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2022


ABSTRACT:
Mesua ferrea Linn., commonly called Nagakesara or Ceylon iron wood belongs to the family Calophyllaceae. The present study deals with the Gas Chromatography Mass Spectroscopy analysis of Mesua ferrea, which have different medicinal properties. The aim of this study was to identify the phytocomponents present in the ethylacetate extract of Mesua ferrea by using Shimadzu GC-MS Model number: QP2010S equipped with Column - ELITE-5MS (30 meter length, 0.25 mm ID, and 0.25 µm thicknesses). Fourteen compounds were identified and which includes (-)-.alpha.-copaene, .alpha.-Bergamotene, (+)-valencene, beta-eudesmene, .alpha.-selinene, .beta.-Bisabolene, 2, 4-ditert-butylphenol, delta.-cadinene, neophytadiene, Phytol, .beta.-Resorcylic acid, 5-(3, 7-dimethyl-2, 6-octadienyl)-6-pentyl-, ethyl ester, (E)-, Squalene, nonadecane, tricosane.


Cite this article:
Sruthikrishna P.K, Sapna Shrikumar. GC-MS analysis of phytocomponents in the ethylacetate extract of Mesua ferrea Linn. leaves. Asian Journal of Pharmaceutical Analysis. 2022; 12(2):121-6. doi: 10.52711/2231-5675.2022.00022

Cite(Electronic):
Sruthikrishna P.K, Sapna Shrikumar. GC-MS analysis of phytocomponents in the ethylacetate extract of Mesua ferrea Linn. leaves. Asian Journal of Pharmaceutical Analysis. 2022; 12(2):121-6. doi: 10.52711/2231-5675.2022.00022   Available on: https://ajpaonline.com/AbstractView.aspx?PID=2022-12-2-10


REFERENCES:
1.    Perumal Rajalakshmi, Vellingiri Vadivel, Natesan Ravichandran, Pemalah Brindha. Investigation on pharmacognostic parameters of sirunagapoo (Mesua ferrea l): a traditional Indian herbal drug. Pharmacognosy Journal. 2019; 11(2): 225-230. doi: 10.5530/pj.2019.11.35.
2.    Nishendu P. Nadpara, Jagruti P. Vaghela, Parula B. Patel. Phytochemistry and pharmacology of Mesua ferrea Linn. – A review. Research J. Pharmacognosy and Phytochemistry 2012; 4(6): 291-296 .
3.    Adiana Mohamed Adib, Nurhanan Murni Yunos, Chee Beng Jin. Anti-cancer, antimicrobial, and antioxidative potentials of Mesua ferrea L. and its phytochemical constituents: a review. Asian Journal of Pharmacognosy. 2019; 3(3): 5-19.
4.    Manoj Tripathi, Alok Kumar, Anil Kumar, Virendra Rajak. Standardization of Stamens of Mesua ferrea Linn. Research Journal of Pharmacognosy and Phytochemistry 2017; 9 (3): 147-151. doi: 10.5958/0975-4385.2017.00027.9.
5.    Choudhury S, Ahmed R, Barthel A, Leclercq PA. Volatile oils of Mesua ferrea (L.). Journal of Essential Oil Research. 1998; 10(5):497-501. doi: https://doi.org/10.1080/10412905.1998.9700955
6.    Kritikar KR, Basu BD. Indian Medicinal Plants. 2Edn, Allahabad. 1956 ;( 171):267270.
7.    Amit Sharma, Surbhi Sharma, Rohit, Naresh and Bharat Parashar. Mesua ferrae linn: - A review of the Indian medical herb. Systematic Reviews in Pharmacy.2017; 8(1):19-23. doi: 10.5530/srp.2017.1.5.
8.    Ronald Hites A. Gas chromatography mass spectroscopy. Hand book of instrumental techniques for analytical chemistry, 1997.p.609-611.
9.    R. Ezhilarasi, B. Senthikumar, K. Devi. GC-MS analysis of bioactive compounds in aqueous extract of Boerhaavia diffusa, Euphorbia hirta and Amaranthus polygonoides. International Journal of Trend in Scientific Research and Development. 2019; 4(1): 65-69. doi: https://www.ijtsrd.com/papers/ijtsrd29 .
10.    Teresa May B. Bandiola. Extraction and qualitative phytochemical screening of medicinal plants: a brief summary. International Journal of Pharmacy. 2018; 8(1): 137-143.
11.    Tulika Tyagi and Mala Agarwal. Phytochemical screening and GC-MS analysis of bioactive constituents in the ethanolic extract of Pistia stratiotes L. and Eichhornia crassipes (Mart.) solms. Journal of Pharmacognosy and Phytochemistry. 2017; 6(1): 195-206.
12.    Cong Z, Meiling Q, Qinglong S, Shan Z and Ruonong F:J. Pharm. Biomed. Anal 2007; 44: 464.
13.    Lee S J, Umano K, Shibamoto T and Lee KG. Identification of volatile components in basil Ocimum basilicum L and thyme leaves Thymus vulgaris L and their antioxidant properties. Food Chemistry. 2005; 91(1): 131-137. doi: 10.1016/j.foodchem.2004.05.056.
14.    Lampronti I, Saab A M and Gambari R. Antiproliferative activity of essential oils derived from plants belonging to the Magnoliophyta division. International Journal of Oncology. 2006; 29(4):989-95. doi: 10.3892/ijo.29.4.989
15.    Haznagy-Radnal E, Czigle S and Mathe I: J. Planar. Chromatogr 2007; 20: 189.
16.    Hasan Turkez, BasakTogar, Abdulgani Tatar, FatimeGeyıkoglu and AhmetHacımuftuoglu. Cytotoxic and cytogenetic effects of α-copaene on rat neuron and N2a neuroblastoma cell lines. Biologia .2014; 69(7): 936–942. doi: https://doi.org/10.2478/s11756-014-0393-5.
17.    Ellappan Paari, Leelavinothan Pari, Thangasamy Gunaseelan, Duraisamy Kannan. Beneficial effects of valencene on altered glycoprotein components in streptozotocin-nicotinamide induced diabetic rats. Journal of Drug Delivery and Therapeutics. 2019; 9(4-A):191-196. doi: http://dx.doi.org/10.22270/jddt.v9i4-A.3393.
18.    In Jun Yang, Dong-Ung Lee, and Heung Mook Shin. Inhibitory effect of valencene on the development of atopic dermatitis-like skin lesions in NC/Nga mice. Evidence-based complementary and alternative medicine. 2016; 1-11. doi: https://doi.org/10.1155/2016/9370893.
19.    Nargella S. Carneiro, Cassia C.F. Alves, Jose M. Alves, Mariana B. Egea, Carlos H.G. Martins, Thayna S. Silva, Lizandra C. Bretanha, Maira P. Balleste, Gustavo A. Micke, Eduardo V. Silveira and Mayker L.D. Miranda. Chemical composition, antioxidant and antibacterial activities of essential oils from leaves and flowers of Eugenia klotzschiana Berg (Myrtaceae). Anais da Academia Brasileira de Ciencias. 2017; 89(3): 1907-1915. doi: http://dx.doi.org/10.1590/0001-3765201720160652.
20.    Mohamad Hesam Shahrajabian, Wenli Sun, and Qi Cheng. Chemical components and pharmacological benefits of Basil (Ocimum basilicum): a review. International Journal of Food Properties. 2020; 23(1): 1961–1970. doi: https://doi.org/10.1080/10942912.2020.1828456.
21.    Bishwanath Acharya, Wanna Chaijaroenkul, Kesara Na- Bangchang. Therapeutic potential and pharmacological activities of β- eudesmol. Chem Biol Drug Des. 2021; 97(4): 984–996. doi: 10.1111/cbdd.13823.
22.    Syn Kokyeo, Ahmed Y Ali, Olivia A Hayward, Daniel Turnham, Troy Jackson, Ifor D Bowen, Richard Clarkson. Beta bisabolene, a sesquiterpene from the essential oil extract of opoponax (Commiphoraguidottii) exhibit cytotoxicity in breast cancer cell lines. Phytother. Res. 2016; 30(3): 418-425. doi: 10.1002/ptr.5543.
23.    Kontham Kulangara Varsha, Leena Devendra, Ganesan Shilpa, Sulochana Priya Ashok Pandey, Kesavan Madhavan Nampoothiri. 2, 4-Di-tert-butyl phenol as the antifungal, antioxidant bioactive purified from a newly isolated Lactococcus sp. Indian J Microbiol. 2016; 56(4):411-416. doi: 10.1007/s12088-016-0597-1.
24.    T.S. Chuah, M.Z. Norhafizah, A.H. Naimah, B.S. Ismail. Phytotoxic activity of the allelochemical, 2,4-di-tert-butylphenol on two selected weed species, sains malaysiana. Sains Malaysiana. 2016; 45(6): 963–967.
25.    Fuqiang Zhao, Ping Wang, Rima D. Lucardi, Zushang Su, Shiyou Li. Natural sources and bioactivities of 2,4-di-tert-butylphenol and its analogs. Toxins. 2020; 12(1), 35. doi:10.3390/toxins12010035.
26.    Zahra Aghajani, Masoud Kazemi, Mohammad Dakhili, Abdolhossein Rustaiyan. Composition and antimicrobial activity of the essential oil of artemisia kulbadica from Iran. Natural Product Communications. 2009; 4(9), 1261 – 1266.
27.    Ibrahim Saleh, Ahmed Abd-ElGawad, Abd El-Nasser El Gendy, Abeer Abd El Aty, Tarik Mohamed, Hazem Kassem, Fahd Aldosri, Abdelsamed Elshamy, Mohamed-Elamir F. Hegazy. Phytotoxic and antimicrobial activities of Teucrium polium and Thymus decussatus essential oils extracted using hydrodistillation and microwave-assisted techniques. Plants. 2020; 9, 716. doi:10.3390/plants9060716, 1-15.
28.    Venkata Raman B, Samuel LA, Pardha Saradhi M, Narashimha Rao B, Naga Vamsi Krishna A, Sudhakar M, Radhakrishnan TM. Antibacterial, antioxidant activity and GC-MS analysis of Eupatorium odoratum. Asian J Pharm Clin Res. 2012; 5(2), 99-106.
29.    S. Prabhu1, S. Vijayakumar, Raju Ramasubbu, P. K. Praseetha, K. Karthikeyan, G. Thiyagarajan, J. Sureshkumar1and N. Prakash. Traditional uses, phytochemistry and pharmacology of Bauhinia racemosa Lam.: a comprehensive review. Future Journal of Pharmaceutical Sciences. 2021; 7(101), 1-18. doi: https://doi.org/10.1186/s43094-021-00251-1.
30.    Md. Adnan, Md. Nazim Uddin Chy, A.T.M. Mostafa Kamal, Md Obyedul Kalam Azad, Arkajyoti Paul, Shaikh Bokhtear Uddin, James W. Barlow, Mohammad Omar Faruque, Cheol Ho Park and Dong Ha Cho. Investigation of the biological activities and characterization of bioactive constituents of Ophiorrhiza rugosa var. Prostrata (d.don) & mondal leaves through in vivo, in vitro, and in silico approaches. Molecules. 2019; 24(7):1367. doi: 10.3390/molecules24071367.
31.    Prabhanna Banakar and M. Jayaraj. GC-MS analysis of bioactive compounds from ethanolic leaf extract of Waltheria indica linn. and their pharmacological activities. IJPSR. 2018; 9(5): 2005-2010. doi: 10.13040/IJPSR.0975-8232.9(5).2005-10.
32.    Shahriar Khadem and Robin J. Marles. Monocyclic phenolic acids; hydroxy- and polyhydroxybenzoic acids: occurrence and recent bioactivity studies. Molecules. 2010, 15, 7985-8005. doi:10.3390/molecules15117985.
33.    B. R. Wagle, K. Arsi, A. Upadhyay, S. Shrestha, K. Venkitanarayanan, A. M. Donoghue, and D. J. Donoghue. Beta-resorcylic acid, a phytophenolic compound, reduces campylobacter jejuni in postharvest poultry. Journal of Food Protection. 2017; 80(8), 1243–1251. doi:10.4315/0362-028X.JFP-16-475.
34.    Jose M. Lou-Bonafonte, Roberto Martinez-Beamonte, Teresa Sanclemente, Joaquin C. Surra, Luis V. Herrera-Marcos, Javier Sanchez-Marco, Carmen Arnal and Jesus Osada. Current insights into the biological action of Squalene. Mol Nutr Food Res. 2018; doi: 10.1002/mnfr.201800136.
35.    E. S. Sumi, R. Anandan, R. Rajesh, C. N. Ravishankar and Suseela Mathew. Nutraceutical and therapeutic Applications of Squalene. Fishery Technology 55(4): 229 – 237.
36.    Zih-Rou Huang , Yin-Ku Lin and Jia-You Fang. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology. Molecules 2009; 14, 540-554; doi: 10.3390/molecules14010540.
37.    Patricia A. Onocha, Ganiyat K. Oloyede and Jamiu A. Akintola. Chemical composition, free radical scavenging and antimicrobial activities of essential oil of Mariscus alternifolius vahl. The Open Conference Proceedings Journal. 2016; 7, 160-167, doi: 10.2174/2210289201607010160.

Recomonded Articles:

Author(s): Shobha Rani G, Lohita M, Jaya Preethi P, Madhavi R, Sunisitha B, Mounika D

DOI:         Access: Open Access Read More

Author(s): Hamid Khan, Javed Ali

DOI: 10.5958/2231-5675.2017.00020.5         Access: Open Access Read More

Author(s): Khushboo Patel*, Dhara Patel, Jaya Dwivedi, Priyanka Newal, Dhananjay Meshram

DOI: 10.5958/2231-5675.2017.00039.4         Access: Open Access Read More

Author(s): Sri Lakshmi D, Jane T Jacob, Srinivasa Sastry D, Satyanarayana D

DOI: 10.5958/2231-5675.2017.00005.9         Access: Open Access Read More

Author(s): Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain

DOI: 10.5958/2231-5675.2015.00025.3         Access: Open Access Read More

Author(s): B. Thangabalan, M. Salomi, N. Sunitha, S. Manohar Babu

DOI:         Access: Open Access Read More

Author(s): Prashanthi. Y, Tentu Nageswara Rao, Yellapu Srinivas

DOI: 10.5958/2231-5675.2018.00034.0         Access: Open Access Read More

Author(s): Md. Ahsanul Haque, Mohammad Shahriar, Most. Nazma Parvin, S. M. Ashraful Islam

DOI:         Access: Open Access Read More

Author(s): Madhavi R., Mohana Krishna A., Shobha Rani G., Mounika D.

DOI: 10.5958/2231-5675.2015.00008.3         Access: Open Access Read More

Author(s): Kathirvel S., Raju R., Seethadevi B., Suneetha A.,Jyothisree K.

DOI: 10.5958/2231-5675.2015.00014.9         Access: Open Access Read More

Author(s): Rohini S. Koli, Aslam S. Patel, Kamlesh N. Chaudhari, Khushbu R. Patil

DOI: 10.5958/2231-5675.2018.00042.X         Access: Open Access Read More

Author(s): Tentu Nageswara Rao, Imad Hussain, Y. Prashanthi, T. B. Patrudu

DOI: 10.5958/2231-5675.2019.00015.2         Access: Open Access Read More

Author(s): G. Kumar, T.B. Patrudu, Tentu Nageswara Rao, M.V. Basaveswara Rao

DOI: 10.5958/2231-5675.2017.00001.1         Access: Open Access Read More

Author(s): D. Narmada, P.V. Murali Krishna, Shaik Mohammad Yusuf, B. Ranganayakulu, K. Uday Praveen, P. Raja Abhilash

DOI:         Access: Open Access Read More

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 

Popular Articles


Recent Articles




Tags