Author(s): Arshiya Zulfeen Mohd Fahim, Mohammed Shakir Ghouse, Syed Qumarul Islam, Mohammed Abdul Mughni Danish, Shaikh Mehmood, Shaikh Saniya, Quraishi Inshrah Fatima

Email(s): ,

DOI: 10.52711/2231-5675.2021.00018   

Address: Ms. Arshiya Zulfeen Mohd Fahim1, Mr. Mohammed Shakir Ghouse2, Mr. Syed Qumarul Islam1, Mr. Mohammed Abdul Mughni Danish1, Mr. Shaikh Mehmood1, Ms. Shaikh Saniya1, Ms. Quraishi Inshrah Fatima1
1Lecturer, Aayan Education and Welfare Trust’s, Aurangabad Pharmacy College, Mitmita, Aurangabad.
2Principal, Aayan Education and Welfare Trust’s, Aurangabad Pharmacy College, Mitmita, Aurangabad.
*Corresponding Author

Published In:   Volume - 11,      Issue - 2,     Year - 2021

Quality by Design (QbD) is a modern, scientific approach that formalizes product design, automates manual test¬ing, and streamlines troubleshooting. It uses a system¬atic approach to ensure quality by developing a thorough understanding of the compatibility of a finished product to all of the components and processes involved in manufac¬turing that product. Olibanum also known as “Dhup”, Indian Frankincense is an oleo gum resin of Boswellia species. In India it is obtained from Boswellia serrata. Boswellia serrata (Burseraceae) The major use of Boswellia serrata in contemporary medicine is as an anti-arthritic and anti-inflammatory pharmacological agent. The anti-inflammatory properties of the gum resin are attributed to the presence of “boswellic acids” The four major pentacyclic triterpenic acids present in the acidic extract of Boswellia serrata gum resin. ß-Boswellic Acid, Acetyl-ß-Boswellic Acid, 11-keto-ß-Boswellic Acid, Acetyl-11-keto-ß-Boswellic Acid. Oleo gum resin was subjected for solubility studies in different solvents. In this 10 commonly available solvents were used for extraction including water. All of them showed same TLC pattern except water. In case of maceration no heat is employed, but the material has to be extracted multiple times with fresh solvent each time. In this method solvent requirement increases. Each time the extract was checked for presence of boswellic acids by TLC to ensure complete extraction. It took 4-5 times repeated extraction for complete extraction of Boswellic acids by maceration. Literature survey reveals that anti-inflammatory activities associated with this resin are completely restricted to presence of Boswellic acids. So focus in experimental work done is placed on isolation of acid fraction of oleo gum resin. As mentioned in the procedures above acid fraction was obtained as white precipitate. This white precipitate was separated, dried and weighed. Amount of acid fraction obtained was determined on weight basis. In the experimental work done isolation of acid fraction was carried out by procedures mentioned in section above. This is common procedure which uses treatment of resin with alkali to convert acid into its salt and then precipitating salt of acid by using mineral acid. Studies were carried out to check variations in amount of acid portion obtained when parameters were altered. Use of 2% KOH followed by dilute hydrochloric acid as mineral acid will be most suitable.

Cite this article:
Arshiya Zulfeen Mohd Fahim, Mohammed Shakir Ghouse, Syed Qumarul Islam, Mohammed Abdul Mughni Danish, Shaikh Mehmood, Shaikh Saniya, Quraishi Inshrah Fatima. Isolation and Identification of Boswellic Acids by Modern Analytical Techniques. Asian Journal of Pharmaceutical Analysis. 2021; 11(2):98-2. doi: 10.52711/2231-5675.2021.00018

Arshiya Zulfeen Mohd Fahim, Mohammed Shakir Ghouse, Syed Qumarul Islam, Mohammed Abdul Mughni Danish, Shaikh Mehmood, Shaikh Saniya, Quraishi Inshrah Fatima. Isolation and Identification of Boswellic Acids by Modern Analytical Techniques. Asian Journal of Pharmaceutical Analysis. 2021; 11(2):98-2. doi: 10.52711/2231-5675.2021.00018   Available on:

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