Author(s): Nguyen Anh Thu

Email(s): ntathu@daihochoabinh.edu.vn

DOI: 10.52711/2231-5675.2021.00022   

Address: Nguyen Anh Thu*
Faculty of Pharmacy, Hoa Binh University, No. 8 Bui Xuan Phai, My Dinh II, Nam Tu Liem, Hanoi, Vietnam.
*Corresponding Author

Published In:   Volume - 11,      Issue - 2,     Year - 2021


ABSTRACT:
Quantification of acetaminophen, caffeine and ibuprofen in ternary mixtures was studied by using UV spectroscopy coupled with multivariate analysis [tri-linear regression-calibration (TLRC), classical least squares (CLS) and multi linear regression calibration (MLRC)]. To validate UV spectroscopic methods, the wavelength range of 215 – 290nm and a matrix (composed of 21 standard solutions containing acetaminophen 20-32.5mg/L, caffeine 1-3.5mg/L and ibuprofen 12-32mg/L) were selected. With the exception of TLRC, CLS and MLRS algorithms proved to be relevant for obtaining UV spectroscopic assay results and dissolution profile of acetaminophen, caffeine and ibuprofen in their combined capsules and tablets, with precision (RSD < 3%) and accuracy (98.3 – 101.9% recovery). It is also suggested that these UV spectroscopic methods could replace UHPLC analysis in the routine quality control of these compounds in their solid pharmaceutical dosage forms (p > 0.05).


Cite this article:
Nguyen Anh Thu. Quantification of Acetaminophen, Caffeine and Ibuprofen in Solid Dosage Forms by UV Spectroscopy coupled with Multivariate analysis. Asian Journal of Pharmaceutical Analysis. 2021; 11(2):127-2. doi: 10.52711/2231-5675.2021.00022

Cite(Electronic):
Nguyen Anh Thu. Quantification of Acetaminophen, Caffeine and Ibuprofen in Solid Dosage Forms by UV Spectroscopy coupled with Multivariate analysis. Asian Journal of Pharmaceutical Analysis. 2021; 11(2):127-2. doi: 10.52711/2231-5675.2021.00022   Available on: https://ajpaonline.com/AbstractView.aspx?PID=2021-11-2-12


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24.     Daharwal SJ and Veena DS. Development of chemometric assisted methods for simultaneous estimation of ternary mixture of telmisartan hydrochloride, amlodipine besylate and hydrochlorothiazide. Asian Journal of Pharmacy and Technology. 2015; 5(2): 122-126.
25.    Sayali SM, Sandeep SS, Santosh SC and Sanjay JK. development and validation of RP-HPLC method for simultaneous estimation of saxagliptin and dapagliflozin in tablets. Asian Journal of Pharmacy and Technology. 2018; 8(3): 145-148.
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29.    Duong TTA and Vu DH. Simultaneous determination of paracetamol and codeine phosphate in combined tablets by first-order derivative and ratio spectra first-order derivative UV spectrophotometry. Asian Journal of Research in Chemistry. 2009; 2(2): 143-147.

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