Author(s): Prem Kumar Bichala, K. Jeevan Kumar, R. Suthakaran, Ch. Shankar

Email(s): prembichala@gmail.com

DOI: 10.5958/2231-5675.2020.00003.4   

Address: Prem Kumar Bichala1*, K. Jeevan Kumar2, R. Suthakaran3, Ch. Shankar3
1Associate Professor, Department of Pharmaceutical Analysis, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, India
2Department of Pharmaceutical Analysis, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, India
3Department of Pharmaceutical Analysis, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 1,     Year - 2020


ABSTRACT:
Teneligliptin in tablet dosage form, using Column Inertsil ODS column C8 (4.6 x 250mm), 5µm particle size, mobile phase Phosphate buffer (PH-3): Acetonitrile (50:50) v/v, detection wavelength at 240nm, at flow rate of 1.0ml/min and the retention time 3.608 and 5.148 min. The correlation coefficient was found to be 0.999 for both the drugs. The Recovery studies were performed for Metformin and Teneligliptin in the range of 50% - 150 %. The % recovery of Metformin and Teneligliptin found to be 99.97 and 100.64 respectively. % RSD for Precision studies of Metformin and Teneligliptin was found to be 0.4 and 0.8. Forced Degradation studies were conducted according to the ICH guidelines and the Drug Product was found to be stable in all conditions. Hence we recommend that this method can be a good approach for the quantification of Metformin and Teneligliptin in combination dosage form and can be adopted for the routine quality control analysis of these drugs.


Cite this article:
Prem Kumar Bichala, K. Jeevan Kumar, R. Suthakaran, Ch. Shankar. Development and Validation of an Analytical Method for the Estimation of Metformin and Teneligliptin in its Bulk and Tablet Dosage Form by using RP-HPLC. Asian J. Pharm. Ana. 2020; 10(1):11-14. doi: 10.5958/2231-5675.2020.00003.4


Recomonded Articles:

Author(s): Sushil D. Patil, Sunil V. Amurutkar, C.D. Upasani

DOI: 10.5958/2231-5675.2016.00030.2         Access: Open Access Read More

Author(s): K. Pramod, Shahid H. Ansari, Javed Ali

DOI:         Access: Open Access Read More

Author(s): Rohit R. Todkar, Pallavi B. Patil, Ganesh B. Vambhurkar, Asha M. Jagtap

DOI: 10.5958/2231-5675.2019.00002.4         Access: Open Access Read More

Author(s): Santosh Gada, Anand Kumar Y, Saritha, C. Mallikarjuna Setty

DOI: 10.5958/2231-5675.2018.00036.4         Access: Open Access Read More

Author(s): Kirthi A, Shanmugam R, Mohana Lakshmi S , Ashok Kumar CK, Padmini K, Shanti Prathyusha M, Shilpa V

DOI:         Access: Open Access Read More

Author(s): Sushil D. Patil, Sayali K. Chaure, Maswood Ahmed Hafizur Rahman, Prajkta U. Varpe, Sanjay Kshirsagar.

DOI: 10.5958/2231-5675.2017.00004.7         Access: Open Access Read More

Author(s): Hamid Khan, Javed Ali

DOI: 10.5958/2231-5675.2017.00020.5         Access: Open Access Read More

Author(s): Duggi Adilakshmi, Abdul Saleem Mohammad, Nuha Rasheed, Kathula Umadevi, Chandana Pasupuleti

DOI: 10.5958/2231-5675.2016.00025.9         Access: Open Access Read More

Author(s): Pinaz A. Kasad, K.S. Muralikrishna

DOI:         Access: Open Access Read More

Author(s): P. Janaki Pathi, N. Appala Raju, G.Parvathalu

DOI:         Access: Open Access Read More

Author(s): Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain

DOI: 10.5958/2231-5675.2015.00025.3         Access: Open Access Read More

Author(s): Khushboo Patel*, Dhara Patel, Jaya Dwivedi, Priyanka Newal, Dhananjay Meshram

DOI: 10.5958/2231-5675.2017.00039.4         Access: Open Access Read More

Author(s): B. Thangabalan, M. Salomi, N. Sunitha, S. Manohar Babu

DOI:         Access: Open Access Read More

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 

Popular Articles


Recent Articles




Tags